In this small proof of concept clinical study from 2011, eight healthy male volunteers were assessed for the impact of short- and long-term boron supplementation on various inflammatory cytokines and steroid hormones. Boron in plasma increased significantly following hours and weekly consumption. Six hours after supplementation showed a significant decrease on sex hormone binding globulin (SHBG), high sensitive CRP (hsCRP) and TNF-α levels. After one week the mean plasma free testosterone increased and the mean plasma estradiol decreased significantly.
Naghii, M. R., Mofid, M., Asgari, A. R., Hedayati, M., & Daneshpour, M. S. (2011). Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 25(1), 54–58. https://doi.org/10.1016/j.jtemb.2010.10.001