This was a six month randomized double blind, placebo controlled trial from 2011, which included 49 type 2 diabetic patients with chronic coronary heart disease and aimed to examine the effects of hawthorn supplementation in this population. There was found to be a significant reduction in TC. LDL-C was reduced by 11% and non HDL-C by 10% compared to baseline in the hawthorn group. A significant decrease in neutrophil elastase was also seen.
Dalli E, Colomer E, Tormos MC, Cosín-Sales J, Milara J, Esteban E, Sáez G. Crataegus laevigata decreases neutrophil elastase and has hypolipidemic effect: a randomized, double-blind, placebo-controlled trial. Phytomedicine. 2011 Jun 15;18(8-9):769-75. doi