In this 2018, systematic review and meta-analysis published in Clinical Rheumatology, the authors reviewed 18 articles written between 2003 and 2016, using recent randomized controlled trials on glucosamine for knee OA to reveal up-to-date findings about this supplement and performed a meta-analysis of some of the outcomes to overcome the unsolved bias in each study. This analysis found glucosamine has the potential to alleviate knee OA pain. Further studies are needed to evaluate the effect of glucosamine on knee function and joint preservation, as well as to evaluate the combined effect with other components, such as chondroitin.
Ogata T, Ideno Y, Akai M, Seichi A, Hagino H, Iwaya T, Doi T, Yamada K, Chen AZ, Li Y, Hayashi K. Effects of glucosamine in patients with osteoarthritis of the knee: a systematic review and meta-analysis. Clin Rheumatol. 2018 Sep;37(9):2479-2487. doi: 10.1007/s10067-018-4106-2. Epub 2018 Apr 30. PMID: 29713967; PMCID: PMC6097075.