This study known as the SmartAge study was a monocenter, randomized, double-masked, placebo-controlled phase 2b trial. The intervention included 89 participants (aged 60-90 years old) and 12-month dietary spermidine supplementation. Researchers suggest that supplementation with dietary spermidine might not act as a memory booster, but rather prevent age-related memory impairment and development of AD.
Schwarz C, et al. Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults with Subjective Cognitive Decline: A Randomized Clinical Trial. JAMA Netw Open. 2022 May 2;5(5):e2213875. doi: 10.1001/jamanetworkopen.2022.13875. PMID: 35616942; PMCID: PMC9136623.