In 2021 this study investigated the efficacy and safety of a combined soy and hop extract on postmenopausal symptoms. Seventy-eight women with moderate or severe menopausal symptoms were recruited for this 12-week, multicenter, randomized, double-blind, placebo-controlled trial. After 12 weeks the treatment group scores decreased by 20.61 points compared with 14.80 points in the placebo group (p < 0.05). Fatigue, paresthesia, arthralgia and myalgia, palpitation and vaginal dryness significantly improved more in the treatment group compared with the placebo.
Kim, H. I., Kim, M. K., Lee, I., Yun, J., Kim, E. H., & Seo, S. K. (2021). Efficacy and Safety of a Standardized Soy and Hop Extract on Menopausal Symptoms: A 12-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Journal of alternative and complementary medicine (New York, N.Y.), 27(11), 959–967. https://doi.org/10.1089/acm.2021.0027