In 2018 this review was published in the prolific journal Nutrients. The authors outline the role of glutamine metabolism and activity in function and proliferation of a number of immune cells. Offering rational for benefits related to glutamine’s ability to regulate the expression of several genes of cell metabolism, signal transduction proteins, cell defense, and repair regulators, and to activate intracellular signaling pathways.
Cruzat V, Macedo Rogero M, Noel Keane K, Curi R, Newsholme P. Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation. Nutrients. 2018 Oct 23;10(11):1564. doi: 10.3390/nu10111564. PMID: 30360490; PMCID: PMC6266414.