In 2021, this 36-week open-label clinical trial was conducted in eight older adults and eight young adults. GlyNAC supplementation for 24 weeks in older adults corrected RBC-GSH deficiency, oxidative stress and mitochondrial dysfunction; and improved inflammation, endothelial dysfunction, insulin resistance, genomic damage, cognition, strength, gait speed and exercise capacity; and lowered body fat and waist circumference.
Kumar, P., Liu, C., Hsu, J. W., Chacko, S., Minard, C., Jahoor, F., & Sekhar, R. V. (2021). Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial. Clinical and translational medicine, 11(3), e372. https://doi.org/10.1002/ctm2.372