In this 2019 review study the opportunity for hesperidin rich diets in benefiting obesity was assessed. The reviewers found evidence supporting hesperidin regulation of lipid and glucose metabolism (through AMPK and PPAR mediation), direct regulation of antioxidant index and anti-apoptosis, indirect mediation inflammation (via NF-κB) for the management of obesity.
Xiong H, Wang J, Ran Q, et al. Hesperidin: A Therapeutic Agent For Obesity. Drug Des Devel Ther. 2019;13:3855-3866. Published 2019 Nov 12. doi:10.2147/DDDT.S227499