Hyaluronic acid: Redefining its role 

In this comprehensive review published in 2020, authors compiled the significant preclinical and clinical data relating to uses for hyaluronic acid in a variety of systems. From ophthalmic, arthritic and cancer management, this truly versatile polysaccharide has significant therapeutic potential. Authors specified the crucial role of HA in skin conditions as healing based on anti-inflammatory, proliferative, or re-modeling phases of skin healing process, binding to “CD44 keratinocyte receptors, leading to their differentiation and increasing their motility.” This recent and comprehensive review offers validation for expanding the therapeutic investigations of several different forms and preparations of HA depending on conditions. 

References:

Abatangelo G, Vindigni V, Avruscio G, Pandis L, Brun P. Hyaluronic Acid: Redefining Its Role. Cells. 2020 Jul 21;9(7):1743. doi: 10.3390/cells9071743. PMID: 32708202; PMCID: PMC7409253.