This comprehensive 2017 review assessed human clinical data that outlined the important relationship between flavonoids from citrus fruits and cardiovascular disease. Several high-profile studies were reviewed such as the prolific Nurses Healthy study, the large-scale Polish study, and a number of Japanese studies. All of which showed bioflavonoids have shown cardioprotective properties through correlations between flavanone intake and a decreased risk of stroke and other cerebrovascular diseases.
Testai L and Calderone V. Nutraceutical value of citrus flavanones and their implications in cardiovascular disease. Nutrients. 2017 9(5): pii E502