Short-term Supplementation with Active Hexose Correlated Compound Improves the Antibody Response to Influenza B Vaccine 

In this randomized, controlled clinical study published in 2013, the researchers wanted to evaluate the effect of AHCC in improving the immune responses of healthy adults to the 2009-2010 influenza vaccine. The results show an increase in natural killer (NK) T cells and CD8(+) cells in the AHCC supplementation group. AHCC supplementation was also shown to significantly improve antibody titers to influenza B, compared to the control group. 

References:

Roman, B. E., Beli, E., Duriancik, D. M., & Gardner, E. M. (2013). Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine. Nutrition research (New York, N.Y.), 33(1), 12–17. https://doi.org/10.1016/j.nutres.2012.11.001