In this randomized, controlled clinical study published in 2013, the researchers wanted to evaluate the effect of AHCC in improving the immune responses of healthy adults to the 2009-2010 influenza vaccine. The results show an increase in natural killer (NK) T cells and CD8(+) cells in the AHCC supplementation group. AHCC supplementation was also shown to significantly improve antibody titers to influenza B, compared to the control group.
Roman, B. E., Beli, E., Duriancik, D. M., & Gardner, E. M. (2013). Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine. Nutrition research (New York, N.Y.), 33(1), 12–17. https://doi.org/10.1016/j.nutres.2012.11.001