Stress-Induced Sensitization: the Hypothalamic–Pituitary–Adrenal Axis and Beyond 

This review of preclinical evidence published in 2015 outlines the long term impacts on the hypothalamic- pituitary- adrenal axis in response to both acute and chronic stress. Highlighting the importance of stress management for long term health. 

References:

Belda, X., Fuentes, S., Daviu, N., Nadal, R., & Armario, A. (2015). Stress-induced sensitization: the hypothalamic-pituitary-adrenal axis and beyond. Stress (Amsterdam, Netherlands), 18(3), 269–279. https://doi.org/10.3109/10253890.2015.1067678