Systematic review: Efficacy and safety of pancreatic enzyme supplements for exocrine pancreatic insufficiency 

The aim of this systematic review and meta-analysis published in 2009, aimed to determine if pancreatic enzyme supplementation is superior to placebo or other supplementation for treating fat malabsorption. Twelve randomized, cross-over, controlled studies were included in this analysis, with data showing that pancreatic enzymes were superior to placebo for fat absorption. The authors conclude that pancreatic enzyme supplementation, not specific to any branded product or specific delivery system, improve symptoms of fat malabsorption in patients with exocrine pancreatic insufficiency. 

References:

TAYLOR, J.R., GARDNER, T.B., WALJEE, A.K., DIMAGNO, M.J. and SCHOENFELD, P.S. (2010), Systematic review: efficacy and safety of pancreatic enzyme supplements for exocrine pancreatic insufficiency. Alimentary Pharmacology & Therapeutics, 31: 57-72. https://doi.org/10.1111/j.1365-2036.2009.04157.x