This 2016 publication is a systematic review of meta-analysis aimed at evaluating the effect of arginine on nitric oxide production, leading to an effect on blood pressure and immune regulation. Seven meta-analysis were included in this review, each showing a significant positive benefit of arginine supplementation in reducing both systolic and diastolic blood pressure in hypertensive adults and pregnant women with gestational hypertension.
McRae MP. Therapeutic Benefits of l-Arginine: An Umbrella Review of Meta-analyses. J Chiropr Med. 2016 Sep;15(3):184-9. doi: 10.1016/j.jcm.2016.06.002. Epub 2016 Sep 10. PMID: 27660594; PMCID: PMC5021928.