As a primary defense system of the body, inflammation is critical in both healing and repair following exposure to a wide array of diverse stimuli. These stimuli can include UV radiation from excessive sun exposure, dietary factors like foods with a high glycemic index foods or high in saturated fats, various allergens like pollen, animal dander, certain foods or cosmetics, harmful chemicals, tobacco, alcohol, stress, microbial infections, cuts, burns and many more (See Figure 9).Short term inflammation is self-limiting and stops as quickly as it starts once healing and repair is under control. However, serious problems arise when inflammation continues
Unfortunately, there are certain curcumin formulations being sold that have safety issues regarding the selection of raw materials and efficacy of study design.
One capsule of NovaSOL® contains over six times the amount of Tween-80 normally found in our diet. Again, Tween-80 is known to be well-tolerated up to 100 mg per day, but the health issues with consumption of larger quantities on a regular basis are unknown.
Most curcumin products have excellent safety profiles, however, Schiborr (2014) reported side-effects from the use of NovaSOL® within a group of 23 human participants including:
- Mild nausea (seven females, three males)
- Vomiting (one female)
- Mild fatigue (one female)
- Mild headache (one female)
- Mild stomach ache (one female)
- Incidental regurgitation (one female)
Unfortunately, NovaSOL’s® use of Tween-80 may be the cause of these side effects, since there is no human biosafety data with NovaSOL’s® serving size of Tween-80. Furthermore, studies using BCM-95® have also reported a higher incidence of side effects including raised liver enzymes, blood thinning effects and worsening of GI symptoms in one study (Chandran and Goel, 2012).