Wheat germ
from Triticum aestivum seed germ
Spermidine, derived from wheat germ belongs to a class of molecules called polyamines. Polyamine levels decrease with age.
Wheat germ has the highest spermidine content at a level of 243 mg/kg followed by legumes, such as soybeans with 207 mg/kg of spermidine. Spermidine can also be found in cheese (depending on the length of the ripening period), mushrooms, mangos, semen and chicken liver.
Technical insights:
- Triticum aestivum seed (Wheat germ) extract standardized through enzymatic processes to 1% spermidine is manufactured in China
- Understanding how enzymatic processes extract spermidine
- Given that wheat germ contains the highest levels of spermidine per kg of any other food source this offers a sustainable source for manufacturers. This of course presents an issue for individuals who are sensitive to wheat proteins such as those in the gluten family. The gluten family of proteins includes gliadin and glutenin. While these levels are typically lower in the wheat germ individuals with celiac disease may have valid concerns. AOR’s suppliers have confirmed that wheat germ -providing spermidine is confirmed to be gluten free. The wheat germ undergoes proprietary enzymatic processes to standardize the amount of spermidine (to 1mg from 100mg of wheat germ extract.) This further mitigates the risk of gluten contamination. However, because this is derived from wheat, anyone with non-gluten wheat sensitivities should not use or consult their healthcare practitioner prior to use.
Ingredient Benefits
Caloric Restriction (CR) Mimetic
Compounds that mimic CR are desirable to promote longer, healthier lifespans without the rigors of restricting diet
Preclinical - Anti-aging and increasing health-span
Pre-clinical studies in yeast, nematodes, fruit flies and mice have shown spermidine extends life span in all these species
Improved memory function
Early intervention of spermidine, starting with 60 years of age should be advised to prevent progression of cognitive decline
Enhanced function of hair follicles
In preclinical studies spermidine promoted hair shaft elongation and prolonged hair growth (anagen)
Cardiovascular effects
Reduced cardiovascular mortality and improved endothelial function
Reduced damage to the cell
Thought to limit brain damage in vitro and in vivo through the restoration of efficient autophagy by dismantling misfolded proteins and dysfunctional mitochondria
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Research on this Ingredient
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