RESEARCH

Collaborator: Dr. Brownlee, Albert Einstein Medical College

Research Summary: This clinical study aims to evaluate the effect of benfotiamine and R‐lipoic acid on blood glycating indices HbA1c, as a marker of diabetes.

Current Status: Completed

Stage: Clinical study

Collaborator: Dr. Qingrong Huang, Rutgers University

Research Summary: This project focused on the development of potent polymethoxylated flavonoids as hypocholesterolemic, antiobesity and anticancer agents.

Current Status: Completed

Stage: Pre-clinical study

Collaborator: Dr. Qingrong Huang, Rutgers University

Research Summary: Bioavailability is a pressing problem not only with pharmaceuticals but also with natural health products. It is estimated that over 40% of all new drugs that are being developed have poor bioavailability. AOR has collaborated with Professor Qingrong Huang and his team to develop a number of delivery forms for improving bioavailability including formation of stable and effective micro and nano‐emulsions, solid lipid particles, organogels, self‐emulsifying nano drug delivery systems and other formulations.

Current Status: Completed

Stage: Pre-clinical study

Collaborator: Dr. John Muscedere, Queen’s University

Research Summary: Lactoferrin (LF), an 80‐kDa, multifunctional glycoprotein of the transferrin family, is distributed widely in humans particularly in secretions of exocrine glands and specific neutrophil granules. The highest concentrations of LF are found in breast milk and colostrum. As an important component of the human innate immune system, it has many appealing properties that may prove effective for the prevention of Nosocomial Infections (NIs). This clinical study evaluated the role of lactoferrin in the prevention of NIs in the critically ill.

Current Status: Completed

Stage: Clinical study

This study analysed the effects that riboflavin has on blood pressure in regard to individuals lacking a specific enzyme that helps the body utilize folate. Collaborator: Dr. Helene McNulty, University of Ulster

This study evaluated the use of riboflavin as a measure to counter high blood pressure associated with pregnancy. Collaborator: Dr. Jobe Modou, University of Gambia and Dr. Andrew Prentice, London School of Hygiene & Tropical Medicine

This research project focused on using pea protein to reduce blood pressure while maintaining healthy kidney function by decreasing the activity of renin (an aspartic protease protein and enzyme secreted by the kidneys). Collaborator: Dr. Rotimi Aluko, University of Manitoba

This project aims to determine if taurine has a role in reducing the abnormal flux of calcium ions and ferrous ions to minimize oxidative and inflammatory damage caused by an iron level overload in heart muscle cells and other tissues. Collaborator: Dr. Michael Sole and Dr. Kevin Kuo, University Health Network, University of Toronto

This project focused on developing formulations to reduce homocysteine (an amino acid) and evaluated the effects on the common markers of cardiovascular diseases. Collaborator: Dr. Christopher Low, University of East Anglia

This study evaluated the effects of benfotiamine and R‐lipoic acid on blood glycating indices HbA1c, as a marker of diabetes. Collaborator: Dr. Brownlee, Albert Einstein Medical College

This clinical study evaluated the role of lactoferrin (a glycoprotein found in breast milk) in the prevention of nosocomial infections (ex. UTIs and respiratory pneumonia) in the critically ill. Collaborator: Dr. John Muscedere, Queen’s University

This study aims to evaluate the role of oral bovine lactoferrin (a glycoprotein found in breast milk) in reducing the rate of mortality, or major morbidity, in very low birth weight preterm infants. Collaborator: Dr. Elizabeth Asztalos, University of Toronto/Sunnybrook Research Institute

This study is evaluating the effect of bovine lactoferrin (a glycoprotein found in breast milk) in reducing neonatal sepsis, mortality rates and anemia in women of reproductive age. Collaborator: Dr. Michael Dibley, University of Sydney

This study tested the effects of Lactoferrin, a milk glycoprotein with anti-inflammatory, immunomodulatory and antimicrobial properties, as a treatment for neonatal sepsis. Collaborator: Dr. Keith Barrington, University of Montréal