Vegan, biologically active forms of folate and B12 in researched doses

  • A combination of folic acid (B9) and vitamin B12 in their active forms
  • Superior to folic acid
  • Required for DNA synthesis and cell repair
  • Supports the healthy development of the fetus during pregnancy
  • Prevents neural tube defects
  • Promotes cardiovascular health
  • Supports mood and cognitive functions
  • Ideal for plant-based and vegan diets
Gluten Free

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Folic acid (or folate) is vitamin B9, a water-soluble vitamin that plays a key role in DNA and RNA synthesis, red blood cell production, the metabolism of proteins, and healthy genetic expression. The body needs folic acid but can’t synthesize it on its own and as such must be consumed from foods or dietary supplements. Lifestyle, diet and some medications and diseases can deplete the body’s folate supply. BioFolate™ contains L-5-methyltetrahydrofolate (L-5-MTHF), the active form of folate that is used in the body.

Taking folate in the form of L-5-MTHF ensures that even those with the MTHFR mutation are able to absorb the folate and avoid deficiency.

AOR Advantage

AOR’s BioFolate™ provides a high dose of the active form of folate combined with a minimal amount of active B12, as folate supplementation can mask a B12 deficiency. In accordance with AOR’s philosophy and quality control standards, all of AOR’s 5-MTHF products contain only the highest purity L-5-MTHF on the market, which is guaranteed to be greater than 99% L-5-MTHF.




BioFolate™ contains the preferred, biologically active forms of folate and vitamin B12. BioFolate™ helps the body to metabolize carbohydrates, fats, and proteins and form red blood cells.


AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproducts.

Adult Dosage

Take one capsule daily with food, or as directed by a qualified health care practitioner.


Folate supplementation can mask a vitamin B12 deficiency. Consult a health care practitioner prior to use if you are uncertain whether or not you are taking adequate vitamin B12.

Main Applications
  • Cardiovascular health
  • Healthy red blood cells
  • Optimal methylation health

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Serving Size: One Capsule

Non-medicinal Ingredients: microcrystalline cellulose, silicon dioxide, sodium stearyl fumarate. Capsule: hypromellose.

Maternal Folate Intake
Study #1: Folate for preterm risk reduction
Published in 2019 this is the most current meta-analysis available relating to folate evaluated 25 studies relating to blood folate concentrations, folic acid supplementation, or dietary folate to the risk of preterm birth. Of the 25 studies included:
– 9 assessed the association between blood folate levels and the risk of PTB,
– 12 examined folic acid supplementation and the risk of PTB,
– 2 studies assessed the association between dietary folate intake and the risk of PTB.
– 1 study examined the association of folic acid supplementation and dietary folate and the risk of PTB,
– 1 study assessed the association of blood and dietary folate with the risk of PTB.
The researchers concluded that higher maternal folate levels were associated with a 28% reduction in the risk of preterm birth (OR 0.72, 95% CI 0.56-0.93). Higher folic acid supplementation was associated with 10% lower risk of preterm birth (OR 0.90, 95% CI 0.85-0.95). Further analysis of a subgroup related a higher maternal folate levels in the third trimester was associated with a lower risk of preterm birth (OR 0.58, 95% CI 0.36-0.94).

Li B, Zhang X, Peng X, Zhang S, Wang X, Zhu C. Folic Acid and Risk of Preterm Birth: A Meta-Analysis. Front Neurosci. 2019 Nov 28;13:1284. doi: 10.3389/fnins.2019.01284. PMID: 31849592; PMCID: PMC6892975.

Study #2: Neural tube defects in pregnancy
This practice guideline document from 2015 was published in the Journal of Obstetrics and Gynaecologists of Canada outlines guidelines for clinicians in folic acid supplementation pre and post-conception for the prevention of neural tube defects. The guideline used literature from websites of health technology assessment and health technology-related agencies, clinical practice guideline collections, clinical trial registries, and national and international medical specialty societies. The review then assessed the costs, risks, and benefits of supplementation of forms available in Canada: as multivitamin tablets with folic acid are usually available in 3 formats: regular over-the-counter multivitamins with 0.4 to 0.6 mg folic acid, prenatal over-the-counter multivitamins with 1.0 mg folic acid, and prescription multivitamins with 5.0 mg folic acid. The comprehensive has a number of official recommendations with a few outlined below:
“1. Women should be advised to maintain a healthy folate-rich diet; however, folic acid/multivitamin supplementation is needed to achieve the red blood cell folate levels associated with maximal protection against neural tube defect.
2. All women in the reproductive age group (12-45 years of age) who have preserved fertility (a pregnancy is possible) should be advised about the benefits of folic acid in a multivitamin supplementation during medical wellness visits (birth control renewal, Pap testing, yearly gynecological examination) whether or not a pregnancy is contemplated. Because so many pregnancies are unplanned, this applies to all women who may become pregnant.
3. Folic acid supplementation is unlikely to mask vitamin B12 deficiency (pernicious anemia). However, they recommend that supplementation is combined with at least 2.6 ug/day of vitamin B12 to mitigate even theoretical concerns.
4. Women at HIGH RISK, for whom a folic acid dose greater than 1 mg is indicated, taking a multivitamin tablet containing folic acid, should be advised to follow the product label and not to take more than 1 daily dose of the multivitamin supplement.
5. Women with a LOW RISK for a neural tube defect or other folic acid-sensitive congenital anomaly and a male partner with low risk require a diet of folate-rich foods and a daily oral multivitamin supplement containing 0.4 mg folic acid for at least 2 to 3 months before conception, throughout the pregnancy, and for 4 to 6 weeks postpartum or as long as breast-feeding continues.
6. Women with a MODERATE RISK for a neural tube defect or other folic acid-sensitive congenital anomaly or a male partner with moderate risk require a diet of folate-rich foods and daily oral supplementation with a multivitamin containing 1.0 mg folic acid, beginning at least 3 months before conception. With higher doses for higher risk groups.”

Wilson RD; Genetics Committee, Wilson RD, Audibert F, Brock JA, Carroll J, Cartier L, Gagnon A, Johnson JA, Langlois S, Murphy-Kaulbeck L, Okun N, Pastuck M; Special Contributors, Deb-Rinker P, Dodds L, Leon JA, Lowel HL, Luo W, MacFarlane A, McMillan R, Moore A, Mundle W, O’Connor D, Ray J, Van den Hof M. Pre-conception Folic Acid and Multivitamin Supplementation for the Primary and Secondary Prevention of Neural Tube Defects and Other Folic Acid-Sensitive Congenital Anomalies. J Obstet Gynaecol Can. 2015 Jun;37(6):534-52. English, French. doi: 10.1016/s1701-2163(15)30230-9. PMID: 26334606.

Cardiovascular Health
Study #1: Homocysteine and B-vitamin Status
In a randomized, double-blind, placebo-controlled trial, 80 men and women aged 50-87 years with total plasma homocysteine concentrations of 8umol/L or greater were randomized to receive a multivitamin/mineral supplement for 56 days while consuming their usual diet. After 8 weeks of treatment, subjects taking the supplement had significantly higher B-vitamin status and lower homocysteine concentration than those given placebo. Folate, vitamin B6 and B12 levels increased by 41.6, 36.5, and 13.8%, respectively, in the supplemented group, whereas no changes were observed in the placebo group.

McKay, D. L., Perrone, G., Rasmussen, H., Dallal, G., & Blumberg, J. B. (2000). Multivitamin/Mineral Supplementation Improves Plasma B-Vitamin Status and Homocysteine Concentration in Healthy Older Adults Consuming a Folate-Fortified Diet. The Journal of Nutrition, 130(12), 3090–3096.
Lonn E, Yusuf S, Arnold MJ, et al. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med. 2006;354(15):1567–1577.


Review: Mood, depression, and cognitive decline
This review conducted in 2002 demonstrates the role of folate in a number of health concerns that arise during aging- particularly in the role of managing depression and impaired cognition. Deficiencies in folate can result in megaloblastic anemias and an increased risk of developing comorbid B12 deficiency. Deficiencies in both folate and vitamin B12 raised plasma concentrations of homocysteine, in epileptic, neurological, psychiatric, geriatric and psychogeriatric patients. This review references a number of clinical studies that demonstrate improvement with folate supplementation in patients with low concentrations of folate in serum, red cells, and cerebrospinal fluid relating to subjective and objective improvements in quality of life for depressive patients, reversible and vascular dementia, with related folate deficiencies.

Reynolds EH. Folic acid, ageing, depression, and dementia. BMJ. 2002;324(7352):1512-1515. doi:10.1136/bmj.324.7352.1512

Study: The association of folate and depression

A meta-analysis from 2017 further corroborated Reynolds conclusions that folate deficiency increased risk for depressive symptoms. Researchers used meta-analytic procedures to evaluate this relationship and found a modest though statistically significant effect size that depressive patients had lower folate levels than those with depression (Hedge’s g = -0.24 (95% CI = -0.31, -0.16), p < 0.001). Concluding that “future research on folate supplementation in depression is warranted and clinicians may wish to consider folate supplementation for patients with depression.”

Bender A, Hagan KE, Kingston N. The association of folate and depression: A meta-analysis. J Psychiatr Res. 2017 Dec;95:9-18. doi: 10.1016/j.jpsychires.2017.07.019. Epub 2017 Jul 22. PMID: 28759846.

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