Curcumin Active™

AOR04247

Fast-acting relief for exercise-induced inflammation

  • High-dose Longvida-optimized curcumin from turmeric
  • Free from rapid breakdown by the body
  • Absorbable, bioavailable and effective
  • Relieves joint pain from exercise or inflammation
  • Increases mobility
  • Vegan capsules

$72.44 available on subscription from $72.44 $57.95 / month

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Curcumin Active is a high dose of fast-acting Longvida-optimized curcumin, effective in easing inflammation from sports or activity-related injuries to joints or muscles. It works quickly to help relieve symptoms that stem from inflammation such as arthritis and chronic pain to help you get back to doing the activities you love.  Longvida-optimized curcumin was specially formulated to address issues with standard curcumin products including low bioavailability, poor absorption and rapid breakdown. Although bioavailability and absorption help determine effectiveness, the key to its success lies with the capacity of Curcumin Active to remain free, unbound and in circulation in the body. Particles are reduced to a nano-particle size, then coated in lipids to ensure the free unbound curcumin reaches the tissues.

Curcumin is also known to help reduce gastrointestinal inflammation, promote healthy cell growth, and provide anti-microbial, anti-inflammatory, wound-healing properties. It also supports liver and gallbladder function, cardiovascular health and much more. This formula provides a high dose in a convenient vegan friendly capsule for fast and sustainable relief.

AOR Advantage

AOR was the first to introduce Longvida® curcumin to Canada in 2011. Although bioavailability and absorption help determine curcumin’s effectiveness, the key lies within its ability to remain free (unbound) in circulation and not rapidly broken down by the liver. In this free form, curcumin can enter the blood stream where it remains stable, concentrated, and effective for up to 24 hours. Studies have shown curcumin is as effective as various common NSAIDs (non-steroidal anti-inflammatory drugs) in osteoarthritis sufferers, though much safer.

NPN

80034700

Discussion

Curcumin Active™ is a high dose of the most absorbable optimized Curcuma longa formula that is free from rapid breakdown. It is traditionally used in herbal medicine as a powerful anti-inflammatory to help relieve severe joint pain and chronic inflammation.

Guarantees

AOR guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, dairy, eggs, fish, shellfish or any animal byproduct.

Adult Dosage

Take one to two capsules daily, or as directed by a qualified health care practitioner.

Cautions

Consult a health care practitioner prior to use if you are pregnant, taking antiplatelet medication or blood thinners, or if you have gallstones, a bile duct obstruction, stomach ulcers or excess stomach acid. Consult a health care practitioner if symptoms persist or worsen. This product contains corn and soy derived ingredients, do not use if you have an allergy.

Main Applications
  • Antioxidant
  • Joint health
  • Cognitive health
  • Immune system support
  • Cellular growth health
Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Serving Size: One Capsule
Longvida® Optimized Curcumin* (from Curcuma longa root)
133.3 mg

* LONGVIDA® is a registered trademark of Verdure Sciences Inc. International patent pending.

Non-medicinal Ingredients: ascorbyl palmitate, soy lecithin (non-GMO), maltodextrin, microcrystalline cellulose, silicon dioxide, stearic acid, sodium stearyl fumarate.

Capsule: hypromellose.

Bioavailability
Study 1:
This preclinical study from 2015 evaluated the aqueous solubility and in vitro anti-inflammatory effects of solid lipid curcumin particle (SLCP) formulations ability to mitigate an LPS induced inflammatory response. The effects were also compared with nontreated curcumin extracts. Efficacy was measured by nitric oxide (NO) and prostaglandin-E2 (PGE2) and interleukin-6 (IL-6) levels. Results found that after treatment SLCPs treatment significantly decreased all three in a dose-dependent manner. The SLCP curcumin also significantly inhibits the transcriptional activity of NF-jB in macrophages and have “improved solubility over unformulated curcumin, and significantly decrease the LPS- induced pro-inflammatory mediators NO, PGE2, and IL-6 by inhibiting the activation of NF-jB.”

Nahar PP, Slitt AL, Seeram NP. Anti-Inflammatory Effects of Novel Standardized Solid Lipid Curcumin Formulations. J Med Food. 2015;18(7):786-792. doi:10.1089/jmf.2014.0053

Study 2:
This 2018 review of the current optimized formulations aiming at improving the bioavailability of commercially available formulations does outline some of the concerns with comparisons. Namely, that many of the studies have been hydrolyzing plasma curcumin, thus AUC curves are difficult to compare for improvement in bioavailability. The review study also lists both Longvida and CurQfen as forms that do facilitate and measure the amount of free forms curcumin. However, authors conclude that study design variability limits the ability to effectively compare formulations.

Jamwal R. Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers [published correction appears in J Integr Med. 2019 Jul;17(4):310]. J Integr Med. 2018;16(6):367-374. doi:10.1016/j.joim.2018.07.001

Osteoarthritis
Study 1:
This 2019 pilot study, examined effects of Longvida® Optimized Curcumin prepared using solid lipid curcumin particles (SLCP) technology in patients with knee osteoarthritis. 42 patients (who completed the study), 25 in the control group and 17 in the study group was considered for study analysis. The study group received the optimized curcumin 80 mg of curcumin from 400 mg capsules twice daily following meals for 90 days. The control group received Ibuprofen (400 mg) once in the morning followed by Placebo (dextrin) in the evening. Outcome measures included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Visual Analog Scale (VAS) scales to assesses knee pain and function, while the degree of knee flexion and swelling were also recorded. Blood biochemistry included: hemogram, blood urea, creatinine, random blood sugar and inflammatory markers viz. PGE2, TNF α, IL6, IL1β and LTB4 were also reviewed. Both groups showed a significant and comparable improvement in VAS and WOMAC scores in alleviating pain with Ibuprofen or optimized curcumin.

Gupte PA, Giramkar SA, Harke SM, et al. Evaluation of the efficacy and safety of Capsule Longvida® Optimized Curcumin (solid lipid curcumin particles) in knee osteoarthritis: a pilot clinical study. J Inflamm Res. 2019;12:145-152. Published 2019 Jun 5. doi:10.2147/JIR.S205390

Study 2:
In a study employing a curcumin formulation with increased bioavailability, 50 patients with knee OA received either 180 mg/day of curcumin or placebo, for eight weeks. There was a significant reduction in pain in patients receiving curcumin, as compared to those receiving placebo.

Nakagawa Y, Mukai S, Yamada S, et al. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo controlled prospective study. J Orthop Sci. 2014;19(6):933-939. doi:10.1007/S00776-014-0633-0.

Study 3:
In a randomized, double-blind, placebo-controlled clinical trial, 331 patients with knee OA received either 1,500 mg/day of mixed curcuminoids or 1,200 mg/day of ibuprofen for four weeks. Primary outcome measures were WOMAC scores of pain, stiffness and function. Secondary outcome measures included a six minute walk distance. All outcome measures improved within either group, over the four-week time course, and there were no differences in degree of improvement between groups.

Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: A multicenter study. Clin Interv Aging. 2014;9:451-458. doi:10.2147/CIA.S58535.

Cognitive Decline
Study 1:
This 2015 randomized, double-blind, placebo-controlled trial examined the effects of Longvida® curcumin – a proprietary solid lipid curcumin formulation (400 mg) on cognitive function, mood and blood biomarkers in 60 healthy adults aged 60–85. The study measured performance and working memory following acute (one and three h after a single dose), chronic (four weeks) and acute-on-chronic (one and three h after single dose following chronic treatment) dosing. Results found that after one hour the curcumin group significantly improved performance on sustained attention and working memory tasks, compared with placebo. Chronic treatment yielded improvements in other determinants of health such as stress reduction, and mood (general fatigue and change in state calmness, contentedness and fatigue induced by psychological stress). Curcumin was associated with significantly reduced total and LDL cholesterol and had no effect on hematological safety measures.

Cox KH, Pipingas A, Scholey AB. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. 2015;29(5):642-651. doi:10.1177/0269881114552744

Study 2:
This 2020 follow up to the above study continued examining the effects of Longvida curcumin on working memory in older adults. In this double-blind, placebo-controlled, parallel-groups trial 80 participants ( 50–80 yo) received either Longvida© (400 mg daily containing 80 mg curcumin) or placebo. Outcome measures were cognitive performance, mood and biomarkers at baseline, four, and 12 weeks after supplementation. The curcumin group demonstrated improved working memory performance at 12-weeks using the Serial Threes, Serial Sevens and performance on a virtual Morris Water Maze; lower fatigue scores on the Profile of Mood States (POMS) at both four and 12-weeks. Mood improvements (reduction in tension, anger, confusion) were seen within the first four weeks.

Cox KHM, White DJ, Pipingas A, Poorun K, Scholey A. Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study. Nutrients. 2020;12(6):1678. Published 2020 Jun 4. doi:10.3390/nu12061678

Q: Is nanotechnology safe?

A: It really comes down to what substance is being discussed. If it’s a natural substance, a food or spice for example, breaking down the particles just makes it easier for the body to digest and absorb, and doesn’t cause a problem. However, if it’s a potentially dangerous substance, then applying nanotechnology is only going to make it more dangerous, for exactly the same reason – the body absorbs it more readily.

The idea of nanotechnology has actually been used for centuries in human nutrition and isn’t that new or novel. All nanotechnology really is, is breaking down a substance into very small particles (flour and icing sugar are two examples). In India, when turmeric is used in a curry, it is often broken down into a very fine powder, and then emulsified and heated in oil to release its full absorption potential. Scientists suspect this is why Indian people benefit from the health-promoting effects of the curcumin, which usually isn’t well absorbed by the body. The technologies applied to our Optimized Curcumin mimic this effect – first it is broken down into a fine (nano-sized) powder, and then the beadlets of curcumin are coated with a lipid matrix. Both of these aspects are equally important for absorption purposes, and this is similar to how Indian people have been consuming curcumin for centuries.

Q: Why does AOR still offer Curcumin-95 if Longvida® curcumin is better?

A: There will always be consumers who abide by holistic philosophy and prefer pure, natural extracts that have not been modified or altered by modern technologies.

Q: What is the most beneficial supplement? Turmeric extract, curcumin or curcuminoids?

A: Curcumin is the only molecule that is studied in majority (99%) of animal and human studies.

Q: What is meant by bioavailability?

A: Bioavailability is the amount of molecule that reaches the target site. In the case of curcumin it is how much curcumin reaches the wrist or knee joint to relieve pain and inflammation.  Many factors can impact bioavailability, including the solubility of the molecule, its resistance to degradation by digestive enzymes, how well it is absorbed and how quickly it is metabolized in the body.

Q: What is curcumin’s bioavailability?

A: Only about 2%, meaning that only 2% reaches the target site. For example, for a 500mg of curcumin-95 only 10mg will reach the target site! Since at least 8g of curcumin is required to detect any measurable levels in the blood, that would mean taking twenty capsules of 500mg curcumin-95!

Q: How does AOR increase curcumin’s bioavailability?

A: AOR uses clinically proven and safe Longvida® curcumin, which uses Solid Lipid ParticleTM (SLP) nanotechnology patented and licensed by the University of California Los Angles (UCLA). This technology enhances bioavailability in the following ways:

  • Increases solubility by reducing particle size to nanometer range. The smaller the particle the higher the solubility. The small size of the particles also improves absorption.
  • SLPTM technology is used to coat the tiny curcumin particles in a fatty coating. This prevents acid, bile and enzyme digestion and also protects the curcumin from being metabolized into other, non-beneficial molecules by the body’s enzymes.

Q: Are AOR’s formulas clinically studied?

 

A: Yes. Recently a human clinical study was conducted on cancer patients (Gota et-al 2010). The study clearly showed that the bioavailability (as measured by free plasma curcumin levels) was at least 100 times higher than that of regular 95% curcumin extract! Not only that but there was a significant reduction of pain and inflammation and improved quality of life in the patients.

 

Q: Besides inflammation, what else can curcumin help with?

A:  Researchers at UCLA are currently looking into the application of bioavailable SLP curcumin for Alzheimer’s disease. Preliminary results are very encouraging, and show that curcumin may help to remove proteins from the brain that are associated with the development of Alzheimer’s disease.