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Estro Adapt

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Estro Adapt

$50.95 CAD

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AOR CODE: AOR04297

A Science Backed Formula for Hormone Balance

  • Promotes breast health

  • Supports toxin metabolism in the liver 

  • Helps balance estrogen levels

Use this product for: Hormonal Health
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Details

Estro Adapt™ includes some of the most important estrogen-modulating nutrients known to support healthy estrogen levels and detoxification. Such ingredients include D-Glucarate, DIM (3,3’-diindolylmethane), hops extract, choline and sulforaphane glucosinolate from broccoli extract. Both environmental toxins and unbalanced estrogen levels are believed to increase the risk of women’s health concerns such as fibroids, breast tenderness, premenstrual syndrome and endometriosis.

Estro Adapt reduces the risk of abnormal cellular growth related to estrogen via various mechanisms. It supports the production of “good” estrogens over “bad” estrogens thanks to DIM, a metabolite of I-3-C. DIM also supports healthy cervical tissue growth. 8PN is a phytoestrogen found in hops shown to reduce abnormal cell growth in breast tissue and interfere with undesirable estrogenic activity. D-glucarate, choline and SGS all support the detoxification of excess or inactivated hormones. Estro Adapt may also support healthy, regular menstruation due to its estrogen-modulating activities.

 Those concerned with the effects of excessive estrogen or environmental toxicity, and women looking for natural support for healthy and regular menstrual cycles should consider Estro Adapt.

Label Info

Discussion

Estro Adapt contains hops and choline. Hops are traditionally used in herbal medicine to help relieve nervousness and choline supports liver function.

Product Variation

Product Code NPN Size
AOR04297 80034912 60 VEGI-CAPS

Supplements Facts

Serving Size: 2 Capsules Amount % Daily
LIFENOL®† Hops extract (15-25:1) 120 mg
Calcium D-Glucarate 150 mg
DIM (3,3’-Diindolylmethane) 108 mg
Choline (bitartrate) 27.6 mg

†LIFENOL® is a registered trademark of Naturex, Inc.

*Produced under patent US2006/010032 licensed from Caudill Seed Inc.

broccoli extract* (300 mg), microcrystalline cellulose, maltodextrin, silicon dioxide, sodium stearyl fumarate. Capsule: hypromellose.

Guarantees

AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Adult Dosage

Take 2 capsules daily with breakfast, or as directed by a qualified health care practitioner.

Cautions

Do not take if pregnant or breastfeeding. Consult a health care practitioner if you are attempting to conceive, taking hormone replacement therapy, birth control pills or other medications, if you have or are predisposed to cancer or a liver disorder, if you develop liver-related symptoms (e.g. abdominal pain, jaundice), depression, and/or related diseases, if symptoms persist or worsen, or for use beyond 3 weeks. Consumption of hops with alcohol, other medications, and/or natural health products with sedative properties is not recommended. Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle, or are involved in activities requiring mental alertness. Discontinue use if you experience joint pain or hot flashes. Discontinue use and consult a health care practitioner if you experience irregular menstruation. May temporarily alter urine colour, consult a health care practitioner if urine does not normalize upon discontinued use.

Source

Natural botanical extracts

Pharmaceutical synthesis

Main Application

Cellular growth & differentiation

Women's health

Detoxification

Liver health

PMS

Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Research

Background

Good vs Bad Estrogens

Estrogen has long been considered a risk factor for a variety of women’s health issues. In fact, the risk of poor breast health has been shown to increase with the number of premenopausal years, when estrogen levels are highest. Research has shown that natural estrogens can also be classified as “good” or “bad”. For example, 16α-hydroxylated (“bad”) estrogen metabolites have stronger estrogen activity and are associated with an increased risk of breast problems, while 2-hydroxylated (“good”) estrogen metabolites are weaker and are not associated with increased risk of estrogen related problems.

Estro Adapt to the Rescue

Fortunately, there are natural solutions available that can help tip the balance towards the “good” estrogens, and to help detoxify and eliminate “bad” estrogens and xenoestrogens. The ingredients in Estro Adapt work together to promote a healthy estrogen balance and to promote the detoxification of harmful substances, thereby helping to promote normal cell growth in women.

Estrogen

Estrogens are very important hormones. Although they are present in both men and women, their best known role is as the primary female sex hormones, and they are thus involved in the development of female characteristics and in the regulation of the menstrual cycle. Estrogens have over 400 different functions in the body, some of which include the maintenance of tissue strength, cardiovascular health, mood, bone health and vision.

Different Types of Estrogen

There are many different kinds of estrogens, which can be confusing. The general term “estrogen” tends to be used to describe all types of estrogens, including naturally occurring estrogen produced in the body, estrogens produced by plants (phytoestrogens) and environmental estrogens (xenoestrogens). What is important to note is that while some estrogens are healthy and beneficial, other types can have negative effects. The differences between so-called “good” and “bad” estrogens have already been discussed briefly. There are also compounds called xenoestrogens that can have negative biological effects.

Xenoestrogens

For example, xenoestrogens, which are synthetic estrogens encountered in the environment, are particularly dangerous. These compounds can be present in synthetic hormones, pesticides and plastics. They do not react in our body the same way as natural estrogens, and can be difficult to eliminate from the body. Xenoestrogens have been associated with disrupted reproductive processes.

How Do the Ingredients in Estro Adapt Help?

D-Glucarate

D-glucarate is a naturally occurring compound that is produced by the body in small amounts and is also found in many fruits and vegetables. D-glucarate plays a very important role in the detoxification of toxins and carcinogens. One very important detoxification pathway in the body is the glucuronidation pathway. Through glucuronidation, toxic substances and even excess levels of estrogen are neutralized, and then eliminated from the body.

Unfortunately, this important detoxification process can be disrupted by the enzyme beta-glucuronidase, which reactivates neutralized toxins. Elevated levels of this enzyme have been associated with an increased incidence of abnormal cell activities in the breast, prostate and colon. This is where D-glucarate comes in. The primary action of D-glucarate is to inhibit the enzyme beta-glucuronidase, thereby promoting detoxification. D-Glucarate may promote normal cell growth in the breast by promoting the excretion of excess estrogen.

3,3’-Diindolylmethane (DIM)

DIM is a naturally occurring phytonutrient found in cruciferous vegetables like broccoli. DIM promotes the formation of 2-hydroxylated estrogen metabolites instead of 16α-hydroxylated estrogen metabolites. This means that DIM helps to push the balance of estrogen in the body towards the production of “good” estrogens and reduces the production of “bad” estrogens. DIM may also block the activation of genes that promote abnormal cell activities and activating genes that help promote normal cell growth.

Hops Extract

8-prenylnaringenin (8PN) is a component found in hops that is a potent phytoestrogen, or plant estrogen. It has been shown to be of equal or greater potency as soy-derived phytoestrogens like genistein. 8PN may help promote normal cell growth in breast tissue by interfering with certain pathways mediated by the estrogen receptor. 8PN has also been shown to prevent angiogensis, which is the formation of blood vessels that feed abnormal masses of cells.

Choline

Choline helps to support liver function and therefore detoxification processes that are carried out in the liver. Since phase II detoxification takes place in the liver, choline is an excellent addition to Estro Adapt to support the detoxification of xenobiotics or excess hormones. Choline is also an important cofactor for methylation, which is a ubiquitous process in the body that helps recycle and detoxify various compounds, including estrogen. Increased choline consumption may also be associated with promoting normal cell growth.

Sulforaphane (SGS, from Broccoli extract)

Sulforaphane is another naturally occurring substance found in the brassica family of vegetables, such as broccoli. Sulforaphane stimulates the natural defenses of the body to prevent or improve chronic disease. It is a natural anti-oxidant and a potent inducer of phase II liver detoxification enzymes. The phase II detoxification enzymes are responsible for eliminating harmful toxins and carcinogens from the body.

 

Research

D-Glucarate

Research has shown that D-glucarate can promote normal cell growth in breast tissue in mice by as much as 70%. Calcium-D-glucarate’s inhibition of beta-glucuronidase also allows the body to excrete estrogen before it is reabsorbed by the body. In this way D-glucarate can help to encourage healthy estrogen metabolism, and prevent elevated estrogen levels. D-glucarate has been shown to lower serum estrogen levels in rats by 23%. Preliminary studies in humans show that D-Glucarate supplements are safe, and have the same effects on beta-glucuronidase in people that they do in animals.

DIM

In cell culture studies DIM has powerful cell protection effects, and has been shown to promote normal cell growth in breast and cervical tissues in vitro. It has also been shown to block the activation of genes that promote abnormal cell activities, while activating genes that help promote normal cell growth.

Human studies also show promising results. DIM is currently used to treat Recurring Respiratory Papillomatosis caused by the Human Papilloma Virus and is in Phase III clinical trials for Cervical Dysplasia. Cervical Dysplasia is condition also caused by the Human Papilloma Virus, and is highly correlated to the development of cervical disorders. Preliminary open-label testing has shown that treatment with DIM successfully resolved moderate to severe cervical dysplasia.

SGS

Research has shown that sulforaphane acts directly to promote normal cell growth and to initiate apoptosis, or death, of abnormal cells through a variety of mechanisms. In regards to women’s health, sulforaphane has been shown to promote healthy cell activities, and to reduce their expression of the estrogen receptor, thereby interfering with the ability of estrogen to bind the receptor and initiate cellular proliferation and growth.

Hops Extract: 8-prenylnaringenin

In vitro, 8PN has been shown to support normal breast cell activities by interfering with certain pathways mediated by the estrogen receptor. 8PN has also been shown to prevent angiogensis (the formation of new blood vessels to feed tumors) both in test tube and animal studies.

8PN has benefits for women with menopause. One double blind randomized cross over study (specifically designed to take into account the high degree of “placebo” effect common with menopausal studies) showed that 8PN reduced hot flashes, night sweats and other menopausal symptoms significantly. In animal studies, it has also been shown to help promote healthy blood vessel function and reduce cholesterol levels. It has been proposed that 8PN may help to prevent the incidence of cardiovascular disease associated with low estrogen levels. Lifenol®’s hops extract is standardized to contain an effective level of 8PN, and has been studied in numerous clinical trials.

Choline

A population-based analysis published in 2008 found that those who consumed the most choline had the lowest risk for abnormal cell activities in the breast. Upon finding certain genetic polymorphisms, the authors concluded that choline may promote normal cell progression, but the mechanisms are not yet clear.

 

Market Trends

Hormonal imbalances especially among women are a relatively common health problem. Unfortunately many conventional methods of treating hormonal imbalances are not always effective or safe.

AOR Advantage

AOR offers a science backed formula that encourages the balancing of female hormones, and that helps to support the liver in detoxifying the body from excess estrogen while also supporting the healthy metabolism of it. Excess estrogen can have negative health consequences related to unhealthy cell activities.

References

Abou-Issa H, Moeschberger M, el-Masry W, Tejwani S, Curley RW Jr, Webb TE. Relative efficacy of glucarate on the initiation and promotion phases of rat mammary carcinogenesis. Anticancer Res 1995 May-Jun; 15(3): 805-10.

Bradlow HL, Telang NT, Sepkovic DW, Osborne MP. “2-hydroxyestrone: the ‘good’ estrogen.” J Endocrinol. 1996 Sep; 150 Suppl: S259-65.

Calcium D-Glucarate Monograph. Alternative Medicine Reviews. 2002. 7(4): 336-339.

Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL and Bjeldanes LF. Pilot Study: Effect of 3,3’-Diindolylmethane Supplements on Urinary Hormone Metabolites in Postmenopausal Women with a History of Early-Stage Breast Cancer. Nutrition and Cancer, 50(2), 161–167.

Heerdt AS, Young CW, Borgen PI. Calcium glucarate as a chemopreventive agent in breast cancer. Isr J Med Sci 1995;31:101-105.

Hong C, Kim HA, Firestone GL and Bjeldanes LF. 3,3′-Diindolylmethane (DIM) induces a G1 cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21WAF1/CIP1 expression. Carcinogenesis, Vol. 23, No. 8, 1297-1305, August 2002.

Miligan SR, Kalita JC, Pocock V, Van de Kauter V, Stevens JF, Deinzer ML, Rong H and De Keukeleire D. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. The Journal of Clinical Endocrinology & Metabolism. 2000; 85(12): 4912-4915.

Muti P, Bradlow HL, Micheli A, Krogh V, Freudenheim JL, Schunemann HJ, Stanulla M, Yang J, Sepkovic DW, Trevisan M and Berrino F. Estrogen Metabolism and Risk of Breast Cancer: A Prospective Study of the 2:16α-Hydroxyestrone Ratio in Premenopausal and Postmenopausal Women. Epidemiology, Vol. 11, No. 6 (Nov., 2000), pp. 635-640.

Pepper MS, Hazel SJ, Hümpel M, Schleuning WD. 8-prenylnaringenin, a novel phytoestrogen, inhibits angiogenesis in vitro and in vivo. Journal of Cellular Physiology. 2003; 99(1): 98 – 107.

Ramirez MC and Singletary KW. Regulation of Estrogen Receptor Alpha Expression in Breast Cancer Cells by Sulforaphane. The FASEB Journal. 2008;22:311.6.

Zeligs MA, Sepkovic DW, Manrique C, Macsalka M, Williams DE and Bradlow HL. Absorption-enhanced 3,3’-Diindolylmethane: Human Use in HPV-related, Benign and Pre-cancerous Conditions. Proc. Am. Assoc. Cancer Res. 2003, Apr; 44.

 

Abstract

8-prenylnaringenin, a novel phytoestrogen, inhibits angiogenesis in vitro and in vivo.

Journal of Cellular Physiology. 2003; 99(1): 98 – 107

Pepper MS, Hazel SJ, Hümpel M, Schleuning WD.

8-Prenylnaringenin is a recently discovered phytoestrogen. Using an in vitro model of angiogenesis in which endothelial cells can be induced to invade a three-dimensional collagen gel within which they form capillary-like tubes, we demonstrate that 8-prenylnaringenin inhibits angiogenesis induced by basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), or the synergistic effect of the two cytokines in combination, with an IC50 of between 3 and 10 M. This effect was seen with bovine microvascular endothelial cells derived from the adrenal cortex (BME cells) and with endothelial cells from the bovine thoracic aorta (BAE cells). The inhibitory effects of 8-prenylnaringenin were found to be roughly equipotent to those of genistein that has previously been shown to inhibit angiogenesis in vitro. Early chorioallantoic membrane (CAM) assay results showed reductions in both vessel lengths and vein diameters, with similar potency in the 8-prenylnaringenin and genistein groups. Similar effects on the CAM vessels were seen when the two substances were co-added. These findings suggest that 8-prenylnaringenin has potential therapeutic applications for diseases in which angiogenesis is an important component.

 

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