From 2020 this was a 28-day, parallel-group, double-blind, randomized controlled trial. Sixty-three healthy adults aged 18–70 with self-reported sleep problems were recruited. The intervention group were randomized to receive either saffron extract (affron; 14 mg twice daily) or a placebo. Saffron was associated with greater improvements in ISI total score (P = .017), RSQ total score (P = .029), and PSD sleep quality ratings (P = .014) than the placebo. Saffron intake was well tolerated with no reported adverse effects.
Effects of Saffron on Sleep Quality in Healthy Adults with Self-Reported Poor Sleep: A Randomized, Double-Blind, Placebo-Controlled Trial
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