Advanced B Complex®

AOR04167

Biologically active full-spectrum B complex

  • Active forms of B-vitamins in a form your body can utilize immediately
  • Balanced ratios and clinically-supported doses
  • Support for energy, stress and burnout, metabolism, and nerve function
  • Supports the function of the brain, nervous system, metabolism and methylation
  • Doesn’t cause niacin “flush”
Gluten Free
Non-GMO
Soy Free
Vegan
Clear

The B vitamin family includes vitamin B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folic acid or folate), and B12 (cobalamin).

Though they have essential roles in the body B vitamins are easily lost from the body through urine and sweat. This fact, combined with other factors such as a modern diet high in processed foods, means that it’s easy to become deficient in B vitamins. Additionally, certain groups, including vegans, vegetarians, and the elderly, are at greater risk for Vitamin B deficiency.

Aging, for example, affects how well you take in and use B12 from foods. Deficiency can lead to numerous health issues, including blood sugar imbalances, neurological disorders, anemia, and depression. The body must convert B vitamins into their active coenzyme forms in order to absorb them. Some people have genetic alterations that reduce their body’s ability to perform these conversions. Vegan-friendly Advanced B Complex® contains all of the B-vitamins in their active coenzyme forms, and in balanced doses to ensure that you get the most out of your B complex.

AOR Advantage
Advanced B Complex® delivers the biologically active and most efficient forms of these vitamins in balanced ratios and research-backed doses.

NPN

80025646

Discussion

Advanced B Complex® is designed to provide the most active forms of B vitamins in the most scientifically discerning ratios that the body can safely utilize. Helps metabolize carbohydrates, proteins and fats for energy and supports tissue and red blood cell formation.

Guarantees

AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Adult Dosage

Take one capsule one to three times daily with food, or as directed by a qualified health care practitioner.

Cautions

Consult a health care practitioner prior to use if you are pregnant or breastfeeding or for use beyond eight weeks. People with thiamine hypersensitivity should not take this product. This product may contain corn, do not use if you have a corn allergy.

Main Applications
  • Stress
  • Energy
  • Healthy aging
  • Brain and mood support
  • B-vitamin deficiency
Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Serving Size: Three capsules
B1 Thiamin (benfotiamine)
100 mg
B2 (Riboflavin-5-phosphate sodium)
7.5 mg
B3 (Niacin – from 388 mg inositol hexanicotinate)
353 mg
B5 (Pantethine, calcium D-pantothenate)
300 mg
B6 (Pyridoxal-5’-phosphate)
100 mg
B12 (Methylcobalamin)
1000 mcg
Folic acid (calcium L-5-MTHF)
1000 mcg
Biotin
500 mcg
Choline bitartrate (provides 240 mg of choline)
600 mg
Inositol (from inositol hexanicotinate, inositol)
393 mg

†85 mg from inositol hexanicotinate, 308 mg from inositol

Non-medicinal Ingredients: Microcrystalline cellulose, dicalcium phosphate, silicon dioxide, sodium stearyl fumarate, hydroxypropyl cellulose. Capsule: hypromellose and chlorophyll.

Cognitive Health
Study 1:
A meta-analysis published in 2015 reviewed studies that evaluated the effects of vitamin B12 and/or folate, when compared to a placebo in the treatment of clinical depression. This analysis reviewed randomized, controlled trials in depressive symptoms and disorders, narrowing 269 manuscripts down to 11 peer-reviewed publications. The results show that short-term use of vitamins – days to weeks – was insufficient to improve depressive symptoms in patients with major depression, however, longer consumption (weeks to years) was effective in reducing the risk of relapse and the onset of clinically significant symptoms in people at risk of major depressive disorders.
https://www.ncbi.nlm.nih.gov/pubmed/25644193

Study 2:
Another systematic review and meta-analysis published in 2019 reviewed all publications with the term “B-vitamins or a variation of that, mood, depress/depression, and terms relating to the design of the study. Studies were included in the analysis if they included at least 3 B vitamins for at least 4 weeks of supplementation. Eighteen articles were included, of which 12 were eligible for the meta-analysis. This review provides evidence for the benefits of B vitamin supplementation in healthy and at-risk populations for stress, but not depressive symptoms. The authors conclude that vitamin B complex supplementation may be particularly beneficial in populations who are at risk, due to poor nutrient and mood status.
https://www.ncbi.nlm.nih.gov/pubmed/31527485

Study 3:
In a cross-sectional study in an indigenous population of India, 303 participants, aged 25-65 years of age were recruited to evaluate the associated of B12 and folate deficiencies and MTHFR C677T gene polymorphism in depression and generalized anxiety disorder. Results show that although vitamin B12 and folate status was not found to be directly associated with depression and GAD, but hyperhomocysteinemia was posing more than three folds and six folds significantly increased risk for depression and GAD, respectively. Further, it seems hyperhomocysteinemia was mediated by vitamin B12 deficiency among depressed and anxious individuals.
https://www.sciencedirect.com/science/article/abs/pii/S2405457718306260

Study 4:
This randomized, double-blind, placebo-controlled clinical trial in Taiwan looked at the effect of multivitamin supplementation, containing vitamins B6, B12 and folic acid, in combination with a cholinesterase inhibitor in Alzheimer’s Disease (AD) patients. The hypothesis for this study is due mainly to the fact that elevated serum homocysteine levels have been associated with the development of AD. The results of this study show that 26 weeks of supplementation decreased homocysteine concentrations, although no significant effects were observed on cognition or the performance of activities of daily living, in comparison to the placebo group.
https://www.ncbi.nlm.nih.gov/pubmed/18042476

Study 5:
The symptoms of premenstrual syndrome (PMS) include depression, stress, mood swings, crying spells, irritability, anger, confusion, sleep disorders, clumsiness, social withdrawal, fatigue, abdominal cramping, breast tenderness, headache, stomachache, back pain, food cravings, bloating, and changes in libido. A systematic review and meta-analysis published in 2016 reviewed the effects of vitamin B6 on PMS symptoms. The results of the meta-analysis confirm the role of continuous B6 supplementation in relieving PMS symptoms.
http://eprints.skums.ac.ir/988/1/16.pdf

Cardiovascular Benefits
Study 1:
A meta-analysis published in 2013 reviewed 14 randomized, controlled trials that assess the effect of B-vitamin supplementation on lowering homocysteine levels and the role on cerebrovascular disease risk. The analysis of all 14 studies showed a reduction in overall stroke events, resulting from the reduction in homocysteine levels, following B-vitamin supplementation, in comparison to control groups. The analysis of the different subgroups of strokes (primary vs secondary, ischemic vs hemorrhagic, etc.) did not show significant differences. These results led the authors to conclude that B vitamin supplementation for homocysteine reduction significantly reduced stroke events, especially in subjects with certain characteristics who received appropriate intervention measures.
https://n.neurology.org/content/81/15/1298

Study 2:
This study aimed to determine the role of vitamin B6 supplementation in myocardial infarction (MI) risk in older women. The Nurses’ Health Study cohort was established in 1976 when 121,700 female registered nurses, 30–55 years of age, completed and returned a mailed questionnaire in order to study the relationship between diet and lifestyle and subsequent disease. The cohort continues to be followed every 2 years by questionnaire to update exposure status and to identify cases of newly diagnosed disease. The results from this study showed that fasting plasma concentration of pyridoxal phosphate was inversely associated with MI risk and plasma B6 levels were correlated with Vitamin B6 supplementation and inversely associated with renal function and body mass index.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833014/

Pregnancy
Study 1:
A systematic review of 22 studies, in more than 1000 children, evaluating the impact of folic acid supplementation on neurodevelopment, with the search, restricted to use of folic acid, randomized clinical trials, and pregnancy terminology, as well as neurodevelopment related terms. The results of these studies show a beneficial effect of folic acid supplementation on neurodevelopment and autism
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165626

Study 2:
Vitamin B12 deficiency is also associated with poor pregnancy outcomes. A placebo-controlled, randomized clinical trial evaluated whether daily oral vitamin B-12 supplementation during pregnancy increases maternal and infant measures of vitamin B-12 status. Oral supplementation of 50 mcg vitamin B12 over a 6 week period post-partum was associated with an increase in material breast milk and both material and infant measures of B12 status. Infant plasma methylmalonic acid and homocysteine concentrations were significantly lower in the vitamin B-12 group as well.
https://www.ncbi.nlm.nih.gov/pubmed/24598885

Study 3:
As with the previous summary, it has been well established that vitamin B12 deficiency is associated with adverse maternal and neonatal outcomes, including developmental anomalies, spontaneous abortions, preeclampsia, and low birth weight. This review looked at the available evidence for vitamin B12 deficiency and poor pregnancy outcomes, as well as the benefits of an adequate 12 status in combatting the issues of increased adverse perinatal outcomes, suggesting that diets rich in B-vitamins, especially B12 or supplementation should be looked to in order to address this public health issue.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561829/

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