Advanced cellular health

  • Stimulates over 350 anti-aging genes
  • Shown to increase health and lifespan in animals
  • Balances blood glucose level
  • 2019 Alive Award winner for Consumer and Retailer Choice in weight management
Gluten Free

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benaGene® is stabilized oxaloacetic acid, the world’s first novel and natural Krebs cycle intermediate compound that is specifically formulated to be highly stable and bioavailable so that a one-a-day dosage is all that is required. benaGene® offers the potential of longevity and vitality and is exclusively available in Canada from AOR.

Caloric restriction is the only method proven to extend human lifespan and health span. benaGene® is a novel caloric restriction mimetic (CR mimetic), mimicking up to 98% of the changes in the genetic expression of over 350 genes in a similar fashion to caloric restriction. While human trials on benaGene’s effects on life extension have not been conducted, human clinical trials have confirmed both reduction in glucose levels and an improved uptake of glucose without negative side effects. benaGene® appears to down-regulate pathways that create and store fat. Mitochondrial and cellular DNA damage is also thought to exacerbate aging, and benaGene® both protects and repairs DNA.

Anyone who is interested in slowing down the aging process will want to consider taking benaGene®, as well as those who suffer from glucose imbalances. benaGene® is a perfect partner for resveratrol and other antioxidants, for even more powerful anti-aging effects.

AOR Advantage

benaGene® is exclusively available in Canada from AOR and was introduced in 2007. It provides a therapeutic dose of oxaloacetate, along with vitamin C for added stability, in a convenient dose of just one capsule per day.




benaGene® contains the first (and patented) thermally stabilized oxaloacetate, a key intermediate in the Krebs Cycle which is involved in cellular energy production. benaGene® provides superior antioxidant protection for the maintenance of good health.


AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal by product.

Adult Dosage

Take one capsule daily with food, or as directed by a qualified health care practitioner.


Do not use if pregnant or breastfeeding. Consult a health care practitioner before use if you have diabetes. Discontinue use and consult a health care practitioner if you experience symptoms of hypoglycemia including feelings of anxiety, dizziness, tremor, sweating, nausea or headache.

Main Applications
  • Antioxidant
  • Anti-aging
  • Glucose metabolism

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Serving Size: One capsule
benaGene™ (3-carboxy-3-oxopropanoic acid)
100 mg
Vitamin C
100 mg

Non-medicinal Ingredients: microcrystalline cellulose, sodium stearyl fumarate.

Capsule: hypromellose.

benaGene®, NAD and Oxidative Stress

benaGene® increases the conversion of NADH to NAD. NAD (nicotinamide adenine dinucleotide) is a niacin-derived coenzyme that is present in all living cells and is critical to the production of ATP – the body’s primary source of all immediate energy. Higher NAD levels are thought to have a stimulatory effect on beneficial genes whilst a high NADH concentration is thought to inhibit beneficial genes. Oxaloacetate has also been found to prevent brain mitochondrial DNA damage in mice.


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Cash A., Modification of the NAD /NADH Ratio Via Oxaloacetic Acid Supplementation to Mimic Calorie Restriction Metabolic Pathways and Increase Lifespan, Anti-Aging Therapeutics Volume XII, American Academy of Anti-Aging Medicine, December 2010.

Cash, A., Oxaloacetic Acid Supplementation as a Mimic of Calorie Restriction. Open Longevity Science, 2009. 3: p. 22-27.

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Hogan D., et al., (2010) Oxaloacetate Enhances Resistance to Fatigue in In vitro Mouse Soleus Muscle. FACSM Division of Physiology, Department of Medicine, UCSD, La Jolla, CA presented at the American College of Sports Medicine.

Nogueira L., (April 2011) Acute Oxaloacetate Exposure Enhances Resistance to Fatigue in in vitro Mouse Soleus Muscle, Division of Physiology, Department of Medicine, UCSD, La Jolla, CA, The Federation of American Societies for Experimental Biology

O’Donnell-Tormey, J., et al., Secretion of pyruvate. An antioxidant defense of mammalian cells. J Exp Med, 1987. 165(2): p. 500-14.

Puntel, R.L., C.W. Nogueira, and J.B. Rocha, Krebs cycle intermediates modulate thiobarbituric acid reactive species (TBARS) production in rat brain in vitro. Neurochem Res, 2005. 30(2): p. 225-35.

Puntel, R.L., C.W. Nogueira, and J.B. Rocha, N-methyl-D-aspartate receptors are involved in the quinolinic acid, but not in the malonate pro-oxidative activity in vitro. Neurochem Res, 2005. 30(3): p. 417-24.

Williams, D.S., et al., Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging Cell, 2009. 8(6): p. 765-768.

Wood, J.P. and N.N. Osborne, Zinc and energy requirements in induction of oxidative stress to retinal pigmented epithelial cells. Neurochem Res, 2003. 28(10): p. 1525-33.

Yoshikawa, K., Studies on the anti-diabetic effect of sodium oxaloacetate. Tohoku J Exp Med, 1968. 96(2): p. 127-41.

Yamamoto, H.A. and P.V. Mohanan, Effect of alpha-ketoglutarate and oxaloacetate on brain mitochondrial DNA damage and seizures induced by kainic acid in mice. Toxicol Lett, 2003. 143(2): p. 115-22.

Zlotnik, A., et al., Brain neuroprotection by scavenging blood glutamate. Exp Neurol, 2007. 203(1): p. 213-20.

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