Advanced cellular health

  • Stimulates over 350 anti-aging genes
  • Shown to increase health and lifespan in animals
  • Balances blood glucose level
  • 2019 Alive Award winner for Consumer and Retailer Choice in weight management
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benaGene® is stabilized oxaloacetic acid, the world’s first novel and natural Krebs cycle intermediate compound that is specifically formulated to be highly stable and bioavailable so that a one-a-day dosage is all that is required. benaGene® offers the potential of longevity and vitality and is exclusively available in Canada from AOR.

Caloric restriction is the only method proven to extend human lifespan and health span. benaGene® is a novel caloric restriction mimetic (CR mimetic), mimicking up to 98% of the changes in the genetic expression of over 350 genes in a similar fashion to caloric restriction. While human trials on benaGene’s effects on life extension have not been conducted, human clinical trials have confirmed both reduction in glucose levels and an improved uptake of glucose without negative side effects. benaGene® appears to down-regulate pathways that create and store fat. Mitochondrial and cellular DNA damage is also thought to exacerbate aging, and benaGene® both protects and repairs DNA.

Anyone who is interested in slowing down the aging process will want to consider taking benaGene®, as well as those who suffer from glucose imbalances. benaGene® is a perfect partner for resveratrol and other antioxidants, for even more powerful anti-aging effects.

AOR Advantage

benaGene® is exclusively available in Canada from AOR and was introduced in 2007. It provides a therapeutic dose of oxaloacetate, along with vitamin C for added stability, in a convenient dose of just one capsule per day.




benaGene® contains the first (and patented) thermally stabilized oxaloacetate, a key intermediate in the Krebs Cycle which is involved in cellular energy production. benaGene® provides superior antioxidant protection for the maintenance of good health.


AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal by product.

Adult Dosage

Take one capsule daily with food, or as directed by a qualified health care practitioner.


Do not use if pregnant or breastfeeding. Consult a health care practitioner before use if you have diabetes. Discontinue use and consult a health care practitioner if you experience symptoms of hypoglycemia including feelings of anxiety, dizziness, tremor, sweating, nausea or headache.

Main Applications
  • Antioxidant
  • Anti-aging
  • Glucose metabolism

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Serving Size: One capsule

Non-medicinal Ingredients: microcrystalline cellulose, sodium stearyl fumarate.

Capsule: hypromellose.

Increased Lifespan

This double-blind study measured the effects of oxaloacetate supplementation on lifespan in Caenorhabditis elegans to determine whether dietary supplementation of citric acid cycle metabolites could mimic the lifespan effects of a reduced dietary intake diet.

The study found that oxaloacetate supplementation increased lifespan in Caenorhabditis elegans most likely by stimulating a pathway that is also stimulated by at least one type of DR, beginning with an increase in NAD+/NADH, and requiring AMPK activity. These results demonstrate that supplementation of the citric acid cycle metabolite, oxaloacetate, influences a longevity pathway, and suggest a tractable means of introducing the health‐related benefits of dietary restriction.

Balanced Glucose Levels / Anti-Diabetic Effect

Because of oxaloacetic acids (OAA) instability, this study used its sodium salt in the animal experiment as well as in the clinical investigation. Both rabbits and dogs were sampled across two studies, with blood glucose levels tested prior to and following administration of OAA-NA.

OAA-Na was found to be effective in treating diabetics, especially those belonging to the so-called Type I. OAA-Na was given only to those patients with a long-standing diabetic condition, and therefore a higher rate of effectiveness will be expected when milder cases are subjected to the treatment.

Mimics Caloric Restriction

Three molecular pathways activated by calorie restriction are also shown to be activated by supplementing the diet with the metabolite oxaloacetic acid.

Dietary supplementation with oxaloacetic acid can successfully mimic some of the molecular longevity pathways seen in calorically restricted animals. Animal studies show an increase in lifespan and other substantial health benefits including mitochondrial DNA protection, and protection of retinal, neural and pancreatic tissues. Human studies with oxaloactate indicate a substantial reduction in fasting glucose levels and improvement in insulin resistance

 Anti-Seizure Properties

This study measured the effects of alpha-ketoglutarate and oxaloacetate on brain mitochondrial DNA (mtDNA) damage and seizures induced by kainic acid were examined both in vivo and in vitro. An intraperitoneal (ip) injection of kainic acid (45 mg/kg) produced broad-spectrum limbic and severe sustained seizures in all of the treated mice. The seizures were abolished when alpha-ketoglutarate (2 g/kg) or oxaloacetate (1 g/kg) was injected intraperitoneally in the animals 1 min before kainic acid administration. In addition, the administration of kainic acid caused damage to mtDNA in brain frontal and middle cortex of mice. These effects were completely abolished by the ip preinjection of alpha-ketoglutarate (2 g/kg) or oxaloacetate (1 g/kg). These results suggest that alpha-keto acids such as alpha-ketoglutarate and oxaloacetate play a role in the inhibition of seizures and subsequent mtDNA damage induced by the excitotoxic/neurotoxic agent, kainic acid.

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