C + Bioflavonoids

AOR04312

Vitamin C complex with the benefits of bioflavonoids

  • More effective than vitamin C alone
  • Provides the same pairing of vitamin C and bioflavonoids as that produced in nature
  • Synergistic effect to protect cells, neutralize toxins
  • Helps support brain, cardiovascular, immunity and overall health
  • Natural citrus bioflavonoids boost the antioxidant activity of Vitamin C
  • Clinically researched ingredients
Gluten Free
Non-GMO
Vegan
Clear
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Vitamin C is considered an essential nutrient because the body cannot produce it on its own. Its benefits include immunity, proper formation of bones, teeth and ligaments, promoting heart health, protecting cells from damage, wound healing, iron absorption and more.

Bioflavonoids are powerful antioxidants in their own right, they are even more powerful when combined with vitamin C, as they are in this AOR formulation. Bioflavonoids, or simply flavonoids, are the pigments found in most plants that give fruits and vegetables their colour. They are potent antioxidants that work together with vitamin C to enhance its antioxidant properties by keeping it active longer.

AOR Advantage

AOR provides a high dose of Vitamin C, enhanced with citrus bioflavonoids. Taking advantage of nature’s synergies is what makes AOR’s Vitamin C more effective than most competing supplements.

NPN

80020056

Discussion

Contains pure vitamin C with citrus bioflavonoids such as narirutin, didymin, hesperidin, and hesperetin among other flavonols, flavanones, flavones and their glycosides. Bioflavonoids and vitamin C work as phenolic antioxidants for the maintenance of good health.

Guarantee

AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Adult Dosage

Take one capsule daily with or without food, or as directed by a qualified health care practitioner.

Cautions

This product contains corn derived ingredients, do not use if you have an allergy.

Main Applications
  • Antioxidant
  • Immunity
  • Vascular health
  • Bones, skin, collagen
Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Serving Size: One Capsule
Vitamin C (ascorbic acid)
900 mg
Citrus Bioflavonoids
25 mg

Non-medicinal Ingredients: Corn dextrin, ascorbyl palmitate, sodium stearyl fumarate. Capsule: hypromellose.

Antioxidant
Study: Synergy of vitamin C and other flavonoids
In this 2011 study examined the antioxidant capacity of fractions of vegetables and pointed to an interesting observation namely that vegetables with a number of flavonoids, the ascorbic acid had over ten times the bioavailability of synthetic Vitamin C. Careful analysis revealed that the tannins and flavonoids such as quercetin were also considerably enhanced by vitamin C.

Ji L, Wu J, Gao W, Wei J, Yang J, Guo C. Antioxidant capacity of different fractions of vegetables and correlation with the contents of ascorbic acid, phenolics, and flavonoids. J Food Sci. 2011 Nov-Dec;76(9):C1257-61.

Study: Hesperidin and hesperetin

A 2015 study investigated the anti-inflammatory and antioxidant effects of two flavonoids: hesperidin and hesperetin. Researchers found that both these flavonoids activated not one, but two distinct pathways/functions of reducing and preventing oxidative damage. This included their ability to scavenge free radicals and also their ability to promote cellular defenses via the ERK/Nrf2 signalling pathway (which promotes multiple antioxidant proteins and detoxification enzymes to protect cells).

Parhiz H, Roohbakhsh A, Soltani F, Rezaee R, Iranshahi M. Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models. Phytother Res. 2015;29(3):323-331. doi:10.1002/ptr.5256

Bioflavonoids and Neurodegenerative Diseases

Study: Hesperetin and neurodegenerative diseases systemic review
In 2020 this systemic review examined in vivo and in vitro models of hesperetin in neurodegeneration. Hesperetin, a flavanone class of citrus flavonoid, is a derivative of hesperidin (found in citrus fruits such as oranges, grapes, and lemons). The review cites a number of studies which demonstrated the effective penetration of flavonoids through the blood brain barrier particularly hesperetin, naringenin, dietary anthocyanin and polyphenols with the correct molecular size, lipophilicity, solubility, and pKa values to make this possible. Regarding neuroprotection this review offers insight into a possible mechanism of action for protection against degenerative plaque formation. Specifically that flavonoids- quercetin, rutin, silibinin, naringin, hesperidin- are natural anti-oxidants, which reduce the oxidative stress (Nrf2, HO-1) and amyloid-beta burden which cause Alzheimers disease. Benefits were also shown in Parkinson’s disease models whereby flavonoids reduce oxidative stress and neuroinflammation in the substantia nigra where degeneration causes motor dysfunction. Tin addition to Alzheimers and Parkinsons disease risks the review also outlines benefits in the following: temporal lobe seizures, ischemia-reperfusion injury (IRI), cadmium-induced neurodegeneration and memory impairment.

Khan A, Ikram M, Hahm JR, Kim MO. Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders. Antioxidants (Basel). 2020;9(7):609. Published 2020 Jul 10. doi:10.3390/antiox9070609

Vitamin C, Bioflavonoids and Cardiovascular Health
Study: in obesity
In this 2019 review study the opportunity for hesperidin rich diets in benefiting obesity was assessed. The reviewers found evidence supporting hesperidin regulation of lipid and glucose metabolism (through AMPK and PPAR mediation), direct regulation of antioxidant index and anti-apoptosis, indirect mediation inflammation (via NF-κB) for the management of obesity. Further, the reviewers found hesperidin was able to improve symptoms such as postprandial hyperglycemia and hyperlipidemia in animal models. It is also able to stimulate the release of cholecystokinin (CCK), an appetite-regulating hormone, naturally suppressing appetite.

Xiong H, Wang J, Ran Q, et al. Hesperidin: A Therapeutic Agent For Obesity. Drug Des Devel Ther. 2019;13:3855-3866. Published 2019 Nov 12. doi:10.2147/DDDT.S227499

Study: Review of human clinicals for flavonoid interventions and CV risk
This comprehensive 2017 review assessed human clinical data that outlined the important relationship between flavonoids from citrus fruits and cardiovascular disease. Several high-profile studies were reviewed such as the prolific “Nurses Healthy study, the large-scale Polish study and a number of Japanese studies. All of which showed bioflavonoids have shown cardioprotective properties through correlations between flavanone intake and a decreased risk of stroke and other cerebrovascular diseases. The benefits were explained by the observations that flavonoids positively affect the endothelial cells of blood vessels, and anti-ischemic effects.

Testai L and Calderone V. Nutraceutical value of citrus flavanones and their implications in cardiovascular disease. Nutrients. 2017 9(5): pii E502

Study: Hesperidin in diabetes
In a 2017 randomized placebo-controlled study, 64 patients with type 2 diabetes were given either 500mg per day of the flavonoid hesperidin or placebo. After 6 weeks of treatment, researchers measured a significant increase in the total antioxidant capacity in those who were given hesperidin, as well as lowered measures of DNA damage from oxidative stress.

Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Hesperidin supplementation alleviates oxidative DNA damage and lipid peroxidation in type 2 diabetes: a randomized double-blind placebo-controlled clinical trial. Phytother Res. 2017 Oct; 31(10): 1539-45

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