Cholesterol Control

AOR04379

A bergamot supplement for balanced cholesterol

  • Maintenance of healthy cholesterol levels, through reduction of total cholesterol, LDL, and triglyceride, and increases in HDL
  • Flavonoids found in bergamot provide antioxidant and anti-inflammatory support for healthy blood vessels
Gluten Free
Non-GMO
Vegan

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With the rise in incidence of cardiovascular events such as strokes and heart attacks causative factors have been more widely investigated. There are many lifestyle factors that can contribute to cardiovascular health, particularly diet. Consumption of highly processed, high fat, low fiber, sugary foods have been linked to increased total cholesterol levels, triglyceride levels, and blood sugar. These three levels have been directly linked as risk factors for the development of diseases such as diabetes, atherosclerosis, metabolic syndrome, heart disease.

As such these are often the targets for treatment as well as prophylaxis. While cholesterol is necessary for a number of physiologic processes in the body, excessive amounts can be detrimental by causing atherosclerosis. Individuals with high cholesterol can reduce overall cholesterol by diet and lifestyle changes as well as drugs or supplements that reduce production or increased excretion of cholesterol. Further the ratio of HDL: LDL is important when discussing cholesterol related risk.

Cholesterol found within the low density lipoprotein (LDL-c) along with excess triglycerides can cause the formation of plaques in blood vessels. This can then lead to narrowing of arteries and oxygen deprivation to certain tissues. However, high density lipoproteins scavenger the blood and tissues for free cholesterol and take it back to the liver for excretion. Glucose dysregulation can shift the ratio towards LDL, and can also increase vascular damage. Traditional treatments aim to stop the production of cholesterol in the liver by inhibiting the key enzyme HMG-CoA reductase. However this approach does not increase HDL to remove the excess cholesterol already present, it does not address the glucose dysregulation, further there are many downstream products also inhibited which can cause significant side effects.  Therefore a multi-targeted approach would be most beneficial.

Bergamot (Citrus Bergamia) found in Cholesterol Control is a citrus fruit found in the coastal Calabrian region of Italy. Bergamot contains diverse and highly concentrated flavonoid profile, making it very beneficial for a number of cardiovascular processes. The polyphenols in bergamot contain properties common to other citrus flavonoids, ie. antioxidant properties. Some of the flavonoids in bergamot have a similar mechanism of action as classic treatment used by cholesterol lowering drugs, with the other flavonoids providing added benefit of also increasing HDL to scavenge free cholesterol. Further, its antioxidant properties can prevent inflammation associated with vascular damage, making this supplement effective in managing the risks associated with cardiovascular concerns.

AOR Advantage

AOR’s Cholesterol Control contains a proprietary extract of bergamot which has been thoroughly researched for its cardiovascular benefits.  Other bergamot extracts may not have the same effects as since they may not be standardized for the same amounts of active ingredients.

 

NPN

80069871

Discussion

The bergamot in Cholesterol Control helps support healthy cholesterol levels, which is important for cardiovascular health.

Guarantees

AOR™ guarantees that all ingredients have been declared on the label. Made without wheat, gluten, nuts, peanuts, sesame seeds, sulfites, mustard, soy, dairy, eggs, fish, shellfish or any animal by-product.

Adult Dosage

Take one capsule daily before a meal containing fat, or as directed by a qualified health care practitioner.

Cautions

Consult your physician before use if you are pregnant, lactating, have a medical condition, or are taking any medication. Keep out of reach of children.

Main Applications
  • Heart health
  • Cholesterol
Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Serving Size: One Capsule
Bergamot fruit extract (25-28% flavonoids)
500 mg

Non-medicinal Ingredients: Maltodextrin,silicon dioxide, sodium stearyl fumarate and gellan gum. Capsule: hypromellose, gellan gum.

Improves Cholesterol Levels
Study #1: Improves cholesterol levels in patients with dyslipidemia

In a prospective, open-label, parallel-group, placebo-controlled study, 77 patients with elevated LDL and triglyceride levels were randomized to one of four groups: placebo, 10-20mg rosuvastatin, 1000mg bergamot alone, and bergamot plus rosuvastatin. Interventions were given for 30 days, after which it was found that both the rosuvastatin group and the bergamot group had a decrease in total cholesterol, LDL, and LDL:HDL ratio compared to the placebo group. Researchers also noted decreases in biomarkers of oxidative vascular damage in these treatment groups. Additionally, improvements to lipid profiles were enhanced when bergamot was combined with rosuvastatin compared to the group given rosuvastatin alone.

Gliozzi M, Walker R, Muscoli S, et al. (2013). Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia. Int J Cardiol. 170(2): 140-5

Study #2: Hypolipemic and hypoglycaemic activity of bergamot polyphenols

In a clinical trial of 237 patients with hyperlipidemia, bergamot extract given daily for 30 days led to reductions in total cholesterol, LDL cholesterol and serum triglyceride levels, and increased HDL cholesterol.

Mollace V, Sacco I, Janda E, et al. (2011). Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies. Fitoterapia. 82(3): 309-16

Study #3: Bergamot reduces plasma lipids, atherogenic small dense LDL, and sublinical atherosclerosis in subjects with moderate hypercholesterolemia

In a prospective clinical trial, 80 patients with moderate hypercholesterolemia were given a bergamot-dervied extract containing 150mg flavonoids (16% neoeriocitrin, 47% neohesperidin and 37% naringin). After 6 months of treatment patients had significantly reduced total cholesterol levels (average decrease by 0.8mmol/L), triglycerides (average reduction of 0.3mmol/L), and LDL cholesterol (average decrease of 0.9mmol/L) and a significant increase in HDL cholesterol by about 0.1mmol/L.

Toth PP, Patti AM, Nikolic D, et al. (2015). Bergamot reduces plasma lipids, atherogenic small dense LDL, and sublinical atherosclerosis in subjects with moderate hypercholesterolemia: a 6 months prospective study. Front Pharmacol. 6: 299

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