Curcumin-95

AOR04004

Traditional support for joint health

  • 95% curcumin from turmeric
  • Traditionally used in Ayurvedic medicine
  • Supports joint health
  • Natural antioxidant
NON-GMO Project
Gluten Free
Vegan

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Turmeric root, a revered East Indian spice, contains several types of curcuminoids, of which curcumin is the most potent and clinically studied. Curcumin-95 is a curcuminoid extract standardized to 95% pure curcumin. Curcumin is a powerful antioxidant and anti-inflammatory and has been traditionally used to treat joint pain and various types of chronic pain, although it has many other benefits. It can help protect cells and prevent oxidation of cholesterol and cell membranes, has antibacterial, antifungal and antiviral effects, blocks abnormal cellular growth, promotes healthy cholesterol levels and supports cardiovascular health.

Curcumin-95 is best used by those looking for a great antioxidant in its most natural form that has not been altered by modern technologies. It is effective for joint pain and arthritis and beneficial for overall maintenance of good health.  For an even more powerful anti-inflammatory, it is worth exploring Longvida Optimized Curcumin products which can be found here.

AOR Advantage

AOR Curcumin-95 was the first standardized 95% curcumin extract on the market. It provides a pure and potent extract at a dose supported by research. AOR Curcumin-95 is great for those who prefer pure, natural extracts for disease prevention and maintenance of overall health.

NPN

80020741

Discussion

Curcumin is used in herbal medicine to help relieve joint inflammation and provides antioxidants for the maintenance of good health.

Guarantees

AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulfites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Adult Dosage

Take three capsules daily with/without food, or as directed by a qualified health care practitioner.

Cautions

Consult a health care practitioner prior to use if you are pregnant, taking antiplatelet medication or blood thinners, have gallstones or a bile duct obstruction, have stomach ulcers or excess stomach acid, or if symptoms persist or worsen with use.

Main Applications
  • Digestive health
  • Antioxidant
  • Joint health
  • Lipid metabolism
  • Healthy cell growth
  • Cardiovascular health
Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Serving Size: One Capsule
400 mg

Non-medicinal Ingredients: potato starch, sodium stearyl fumarate. Capsule: hypromellose.

Decreases Joint Pain and Inflammation in Arthritis

Study #1:

In a pilot study of 45 patients with rheumatoid arthritis, subjects were randomized into one of three intervention groups: 1) 500 mg curcumin, 2) 50 mg diclofenac sodium, or 3) 500 mg curcumin + 50 mg diclofenac sodium. Patients in the curcumin group showed the highest percentage of improvement (based on Disease Activity Scores and reduction in tenderness and swelling of joints based on the American College of Rheumatology scores) and these scores were significantly better than from those patients in the diclofenac sodium group. Researchers also noted that curcumin was well-tolerated and wasn’t related to any adverse effects during the study.

Chandran B, Goel A. (2012). A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. 26(11): 1719-25

Study #2:

In an animal model of arthritis, rats with established arthritis were treated orally with either betamethasone, olive oil or curcumin, and one group of non-arthritic rats were used as a control. Treatment with curcumin led to significant differences in average white blood cell count, and bone and cartilage erosion scores compared to the olive oil group. Treatment with curcumin had similar efficacy to betamethasone in protecting against the degenerative changes in arthritic joints.

Kamarudin TA, Othman F, Ramli ESM, et al. (2012). Protective effect of curcumin on experimentally induced arthritic rats: detailed histopathological study of the joints and white blood cell count. EXCLI J. 11: 226-36

Study #3:

In an animal model of rheumatoid arthritis, rats subjected to collagen-induced arthritis were placed into one of three groups: treatment with either curcumin (200 mg/kg) or with the mTOR inhibitor rapamycin daily for three weeks, or no treatment. Curcumin treatment was as effective as rapamycin in inhibiting inflammation (redness and swelling) of the joints in arthritic rats. Both treatments inhibited the increase in proinflammatory cytokines including IL-1B, TNF-alpha, MMP-1, and MMP-3.

Dai Q, Zhou D. Xu L and Song X. (2018). Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathways in rats. Drug Des Devel Ther. 12: 4095-4105

 

Improves Cardiovascular Health and Lipid Metabolism

Study #1:

In an animal study, wister rats were subjected to either biliary duct ligation (BDL) which acted as a model of biliary cholestasis, or to a sham procedure. BDL rats had significantly decreased expression of SIRT3, AMPK, MnSOD, CPT-1A, and IDH2 compared to sham rats. However, in the BDL rats treated with curcumin (100 mg/kg/day), the expression of these factors significantly increased compared to untreated BDL rats. Additionally, BDL rats treated with curcumin had significantly reduced livery injury, reduced levels of total cholesterol, triglycerides and LDL cholesterol and an increase in HDL cholesterol.

Chenari S, Safari F, Moradi A. (2017). Curcumin enhances liver SIRT3 expression in the rat model of cirrhosis. Iran J Basic Med Sci. 20(12): 1306-11

Study #2:

In an animal model of atherosclerosis using apoE/LDL-receptor double-knockout mice, apoE knockout mice treated with curcumin (20 mg·kg–1·d–1) for four months reduced atherosclerotic lesions by 50%. In the second portion of this study, in vitro exposure of curcumin to rat vascular smooth muscle cells pretreated with ox-LDL showed that curcumin inhibited ox-LDL-induced cholesterol accumulation in the cultured vascular cells.

Yuan H-Y, Kuang S-Y, Zheng X, et al. (2008). Curcumin inhibits cellular cholesterol accumulation by regulating SREBP-1/caveolin-1 signalling pathway in vascular smooth muscle cells. Acta Pharmacol Sin. 29(5): 555-63

Study #3:

In an animal study, rats fed a high-fat diet and treated with curcumin for eight weeks showed significantly decreased serum triglyceride levels by 27%, total cholesterol by 33.8%, and LDL cholesterol by 56% respectfully as compared to the non-treated (control) group. Curcumin treatment in high-fat fed rats also significantly lowered the atherogenic index by 48% compared to control, and significantly reduced liver triglyceride levels by 41%.

Kim, M and Kim Y. (2010). Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high-fat diet. Nutr Res Pract. 4(3): 191-5

 

Ulcerative Colitis

Study #1:

In an open-label study , five patients with ulcerative proctitis and four patients with Crohn’s disease were given curcumin (1100 mg daily for one month, then 1650 mg daily for an additional month; and 570 mg daily for one month, then 2010 mg for two months, respectively). All patients that participated had significantly decreased symptoms and decreases in inflammatory markers (ESR and CRP).

Holt PR, Katz S, Kirshoff R. (2005). Curcumin therapy in inflammatory bowel disease: a pilot study. Digestive Diseases and Sciences. 50: 2191-3

Study #2:

In another study, curcumin was used as maintenance therapy in 89 patients who had ulcerative colitis (UC) that was in remission.  In this randomized, double-blind trial, the addition of 2 g per day of curcumin to UC medications sulfasalazine or mesalamine showed a reduced rate of relapse compared to those who were given UC medications only. The curcumin group had a relapse rate of 4.65% compared to 20.5% in the placebo group.

Hanai H, Iida T, Takeuchi K, et al. (2006). Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. 4(12): 1502-6

Study #3:

In an animal model of gastric ulcer researchers compared the effect of curcumin against the H2-antagonist Ranitidine – a drug commonly used for its anti-ulcer effects. Treatment with curcumin extract protected the gastric mucosal layer with the same efficacy as Ranitidine. It also comparably inhibited ulcer formation.

Kim DC, Kim SH, Choi BH, Baek NI, Kim D, Kim MJ, Kim KT. Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors. Biol Pharm Bull. 2005 Dec; 28(12): 2220-4

 

Liver/NAFLD

In an animal study, wister rats were subjected to either biliary duct ligation (BDL) which acted as a model of biliary cholestasis, or to a sham procedure. BDL rats had significantly decreased expression of SIRT3, AMPK, MnSOD, CPT-1A, and IDH2 compared to sham rats. However, in the BDL rats treated with curcumin (100 mg/kg/day), the expression of these factors significantly increased compared to untreated BDL rats. Additionally, BDL rats treated with curcumin had significantly reduced livery injury, reduced levels of total cholesterol, triglycerides and LDL cholesterol and an increase in HDL cholesterol.

Chenari S, Safari F, Moradi A. (2017). Curcumin enhances liver SIRT3 expression in the rat model of cirrhosis. Iran J Basic Med Sci. 20(12): 1306-11

 

Diabetes

In a randomized, double-blind, placebo-controlled study, 240 subjects, 35 years of age or older and diagnosed with unmedicated prediabetes (fasting plasma glucose 100-124 mg/dL, oral glucose tolerance test result between 140-199 mg/dL and HbA1C of 5.7-6.4%) were randomized to 1500 mg curcumin or placebo daily for nine months. All subjects were educated in healthy lifestyle and diet recommendations for three months before the randomization. After nine months of treatment, HOMA index results for insulin resistance were significantly lower in the curcumin group compared to placebo. As well, the curcumin group showed significantly lower mean differences in HbA1C, oral glucose tolerance test results and fasting plasma glucose from baseline and compared to placebo at three, six and nine months.

Chuengsamarn S, Rattanamongkogul S, Leuchapudiporn R, et al. (2012). Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 35(11): 2121-7

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