Gandha-600

Ashwagandha extract

  • A powerful Ayurvedic adaptogen that promotes overall well-being
  • Helps with chronic stress, low energy and endurance
  • Promotes anti-anxiety and antistress responses
  • Supports the immune system
  • High-dose
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Gluten Free
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Ashwagandha is one of the most revered and widely used plants in traditional Ayurveda, the medicine of ancient India, and is the ideal supplement for those facing constant stress and chronic fatigue. Also known as Indian ginseng, it is considered a rejuvenative tonic, supporting energy and vitality. Gandha-600 is an extract of Withania somnifera (ashwagandha), properly standardized for its two main medicinal components: withanolide and sitoindoside.

In North America, ashwagandha is becoming widely known as an adaptogen; an herb that protects against the effects of the body’s stress response. Stress, especially chronic stress, can lead to the development of digestive issues, vitamin C depletion, adrenal exhaustion, decreased libido and sexual function, poor physical endurance, and increased anxiety. Ashwagandha reduces these effects of stress, helps to conserve mental energy, and supports the immune system. Gandha-600 is an extract of ashwagandha, properly standardized for its two main anti-inflammatory and anti-stress components: withanolide and sitoindoside.

AOR Advantage

Botanical extracts must always be standardized to ensure reliable, consistent results for users. The first active compounds discovered in ashwagandha were withanolides. Recently, a derivative group of withanolides, called sitoindosides, were identified and appear to be responsible for much of the herb’s anti-stress and anti-anxiety activities. AOR’s Gandha-600 is standardized for both withanolides and sitoindosides. Just one capsule daily provides the recommended dosage: 600mg of a potent 10:1 extract.

NPN

80023482

Discussion

Gandha-600 contains ashwagandha, a plant widely used in Ayurvedic medicine. Ashwagandha is traditionally used as Rasayana (rejuvenative tonic), to relieve general weakness and stress, especially in old age, as a sleep aid, to balance aggravated Vata (sedative), and for memory enhancement.

Guarantees

AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Adult Dosage

Take one capsule daily with/without food, or as directed by a qualified health care practitioner.

Cautions

Consult a health care practitioner prior to use if you are pregnant or breastfeeding. Consumption with alcohol, other drugs or natural health products with sedative properties is not recommended.

Main Applications
  • Stress
  • Edema
  • Support for tense muscles
  • Veta constitutional
Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Serving Size: One capsule
Ashwagandha (Withania somnifera)
600 mg

Note: Herbal extracts will naturally vary in colour from one batch to another.

Non-medicinal Ingredients: Sodium stearyl fumarate and sodium benzoate.

Capsule: hypromellose.

Stress
Ashwaghanda in Stress-Related Weight Gain
This study published in 2017 examined the role of ashwagandha (n=25, placebo n=25) in reducing perceived stress and subsequent weight gain in healthy subjects over 8 weeks of supplementation. The outcome measures used for assessment included a validated perceived stress questionnaire) PSS), Food Cravings Questionnaire-Trait (FCQ-T), Oxford Happiness Questionnaire (OHQ), Three-Factor Eating Questionnaire (TFEQ), serum cortisol, initial and final body weight and body mass index scores were also recorded. Baseline, four-week, and eight-week measurements were recorded with subject in the intervention group taking 300mg of a standardized extract two times per day. The results indicated statistically significant improvements in both the primary and secondary measures as compared to the placebo. Indicating this may be a good option for the management of stress.

Choudhary D, Bhattacharyya S, Joshi K. Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial. J Evid Based Complementary Altern Med. 2017;22(1):96-106. doi:10.1177/2156587216641830

Ashwagandha in Chronic Stress
In this 2012 RCT, 64 subjects (32 in placebo and 32 in the intervention group) with a history of chronic stress were evaluated for 60 days. The intervention group received 300mg BID of a full spectrum ashwagandha extract, compliance was good with only three dropouts reported. Four validated questionnaires were used as a measure of stress and anxiety (GHQ-28, DASS- anxiety insomnia and stress subset, and PSS), and secondary measures included impacts on stress such as serum cortisol. On all metrics, the treatment arm showed statistically significant improvements compared to the placebo. Including a 44% decrease in the PSS scores compared to the 5.5% reduction in the placebo group.

Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-262. doi:10.4103/0253-7176.106022

Ashwaghanda in Stress Response
In a two-month RCT published in 2019, participants (n=60) were given standardized Withania somnifera extract (240 mg daily) successfully reduced the production of stress hormones, lowering both morning and overall cortisol (23%), and DHEA-S and increasing testosterone levels in males (P = .038) but not female participants. In addition, the treatment group reported a 41% reduction in HAM-A scores measuring anxiety vs 24% in the placebo group.

Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract. Medicine (Baltimore). 2019;98(37). https://pubmed.ncbi.nlm.nih.gov/31517876/ 

Dose-Dependent Ashwaghanda for Stress
This 2019, eight-week randomized double-blind placebo-controlled study of 58 participants examined the dose-dependent effects of aqueous ashwagandha root extract on otherwise healthy participants facing stress and anxiety. Primary outcome measures were PSS, HAM-A scores with secondary measures being serum cortisol and sleep quality scale. The ashwagandha groups were given 125 mg, 300 mg, or placebo BID for eight weeks. Measurements were taken at baseline, four, and eight weeks for outcomes. The 300 mg group had the most pronounced decrease in PSS scores from baseline. While serum cortisol was reduced in both treatment groups the 300mg group was slightly more pronounced. Finally, the HAM-A scores were only statistically significant in the 300mg group as compared with placebo meaning the ashwagandha may not be effective in treating anxiety at low doses.

Salve J, Pate S, Debnath K, Langade D. Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Cureus. 2019;11(12):e6466. Published 2019 Dec 25. doi:10.7759/cureus.6466

Anxiety
Anxiety Review
This 2014 review examined five human clinical trials using Withania at varying doses as a monotherapy in anxiety management. Authors found that of the five available studies many were at high risk of bias. However, the review is being included as it demonstrates that limited availability yet the results of all studies pointed to strong evidence of safety with little to no adverse reactions and could be used as the basis for future more robust studies as three of five studies showed a dose-dependent statistically significant improvement compared to placebo, one studied neared this significance but was too short, and the last study was

Pratte MA, Nanavati KB, Young V, Morley CP. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). J Altern Complement Med. 2014;20(12):901-908. doi:10.1089/acm.2014.0177

Miscellaneous Conditions

Being Studied in Non-restorative Sleep Conditions
This ongoing study is to identify the impact of Withania on the specific nonrestorative sleep concern with insomnia. Results are pending publication

Deshpande A, Irani N, Balakrishnan R. Study protocol and rationale for a prospective, randomized, double-blind, placebo-controlled study to evaluate the effects of Ashwagandha (Withania somnifera) extract on nonrestorative sleep. Medicine (Baltimore). 2018;97(26):e11299. doi:10.1097/MD.0000000000011299

Ashwaghanda in Schizophrenia
This 2018 randomized double-blind placebo-controlled study was conducted in 66 patients with exacerbations in their schizophrenia management. Patients were assigned 1000 mg/day of withania extract ( n=33) or placebo ( n=33.) Primary outcomes Positive and Negative Syndrome Scale (PANSS total, positive, negative, and general symptoms) while secondary outcomes evaluated stress and inflammatory indices using the Perceived Stress Scale (PSS), S100 calcium-binding protein B (S100B), and C-reactive protein (CRP). The study was conducted over 12 weeks. The treatment group demonstrated significantly greater reductions in PANSS negative, general, and total symptoms when compared to placebo. PSS scores improved significantly while CRP and S100B declined more in the treatment group.

Chengappa KNR, Brar JS, Gannon JM, Schlicht PJ. Adjunctive Use of a Standardized Extract of Withania somnifera (Ashwagandha) to Treat Symptom Exacerbation in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study. J Clin Psychiatry. 2018;79(5):17m11826. Published 2018 Jul 10. doi:10.4088/JCP.17m11826

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