Tri B12 Synergy


Combines three different forms of vitamin B12

  • Combines three different forms of vitamin B12: hydroxycobalamin, adenosylcobalamin and methylcobalamin
  • High dose of bioavailable and active forms of B12
  • Clean sourcing from Europe


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Gluten Free

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AOR’s Tri B12 Synergy is a combination of three independent and active forms of Vitamin B12. Methylcobalamin, Hydroxocobalamin and Adenosylcobalamin are three distinct cobalamin factors, each with their own unique benefits. When taken together, they provide an appropriate dose of bioavailable and active forms of B12 for comprehensive support in replenishing a deficiency. Vitamin B12 deficiencies can be caused by poor diet, impaired microbiota, or malabsorption, which is caused by diseases such as Crohn’s or Celiac or use of proton pump inhibitors such as antacids. Populations at particular risk include the elderly, vegans, smokers, chronic antibiotic use and even genetic factors. AOR has sourced its ingredients from European suppliers certified under the “Green Chemistry” certification system.

Vitamin B12 is used as a co-factor in enzymatic processes, which facilitate reactions in the body, like a key turning on a car ignition. Each form of cobalamin – methyl, hydroxyl, adenosyl – is vital to different cellular processes. Because in their absence key physiologic processes are compromised, a deficiency in B12 may cause a variety of symptoms over time, from fatigue to increased cardiovascular risks, poor balance, and cognitive changes or depression.

Methylcobalamin is involved in the critical metabolic process called methylation, as well as the production of red blood cells, neurotransmitter and DNA synthesis, and homocysteine recycling, which is important for heart health.

Adenosylcobalamin is active within the mitochondria (the powerhouse) of cells to support metabolic function, including carbohydrate and fat metabolism, energy production and to maintain a healthy nervous system.

Hydroxocobalamin acts as a precursor to both the above forms and has independent detoxifying actions. It is also bound to the body’s own transport molecules and serves as storage for later conversion, ensuring a longer lasting supply.

AOR Advantage

AOR’s Tri B12 Synergy presents vitamin B12 in its three most active and bioavailable forms. AOR’s ingredients are environmentally-certified pursuant to the “Green Chemistry” certification system.




Methylcobalamin, Hydroxocobalamin and Adenosylcobalamin are active sources of vitamin B12, each form with its own unique benefits. When combined, they quickly help replenish any Vitamin B12 deficiency in the body and assist it in metabolizing carbohydrates, fats and proteins. They also help in the formation of red blood cells.


AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal by-product.

Adult Dosage

Dissolve one lozenge under the tongue first thing in the morning, or as directed by a qualified health care practitioner.


Consult a health care practitioner for use beyond four months. If you are pregnant or breastfeeding, consult a health care practitioner prior to use.

Main Applications
  • Vitamin B12 Deficiency
  • Malabsorption issues
  • High risk groups

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Serving Size: One Lozenge
Vitamin B12
5 mg
3.5 mg
500 mcg

Non-medicinal Ingredients: Hydroxypropyl cellulose, ascorbyl palmitate, tapioca syrup, xylitol, microcrystalline cellulose and distilled water.

In a review on the several forms of vitamin B12, authors Thakkar and Billa (2015) state that both methylcobalamin and adenosylcobalamin are essential with their own distinct functions. They concluded that it would be more beneficial to treat a vitamin B12 deficiency with a combination of methylcobalamin and adenosylcobalamin or hydroxocobalamin (or cyanocobalamin). As well, oral supplementation (ie. tablet, capsule or liquid) has been shown to be as effective as an intramuscular injection for treating a B12 deficiency.

In a 2016 review by Rizzo et al., the authors describe the unique function(s) of each form of cobalamin: Cyanocobalamin and hydroxycobalamin are provitamin forms of B12 that require activation by methylcobalamin or adenosylcobalamin. Adenosylcobalamin works within the mitochondria of cells and when it becomes deficient, this can lead to disrupted communication between nerve cells. Methylcobalamin is responsible for recycling and reducing levels of homocysteine (a marker of cardiovascular disease). The authors also noted that in cases of genetic mutations (also called “polymorphisms”), alternative forms of cobalamin such as methylcobalamin and hydroxycobalamin could improve the effectiveness of supplementation in vegetarians, who are at risk of a B12 deficiency.

A prospective observational study tested the efficacy of using methylcobalamin B12 to treat anemia in children. In this study 28 children with macrocytic anemia (a form of anemia where red blood cells are larger than normal, due to either a vitamin B12 or folate deficiency) were supplemented with methylcobalamin for one month. At the end of the treatment period there was a significant increase in hemoglobin levels, and a significant improvement (decrease) in red blood cell size. Researchers also noted significant improvements in platelet counts and vitamin B12 levels.


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