Natural supplement to maintain healthy veins
- Clinically effective ingredient ratios
- Supports vein integrity and function
- Helps reduce the risk of varicose veins
- May help enhance the appearance of leg veins
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Chronic Venous Insufficiency (CVI) is a condition characterized by a weakening of the walls and valves of veins in the legs that bring blood back to the heart. One of the first and most common symptoms of CVI is varicose veins, but other symptoms can include swelling of the legs, itchy or painful legs, and even leg ulcers.
VeinEase promotes healthy vein function, especially in the legs. The ingredients in VeinEase help maintain healthy vein structure and function, and reduce blood pooling and fluid build-up in the legs. VeinEase provides clinically proven doses and ratios of the flavonoids diosmin and hesperidin, complemented by grape seed extract to provide a natural relief for those with CVI, poor circulation, painful veins or varicose veins. As an added bonus, the nutrients in VeinEase also have cardiovascular benefits. Grape seed extract is known to support healthy blood pressure, and ensuring that blood is returning to the heart from the legs is essential for adequate cardiovascular function.
Daflon 500 is a drug sold in other countries that combines a 10:1 ratio of diosmin and hesperidin. AOR’s VeinEase is unique in that it combines this clinically tested combination and ratio of diosmin and hesperidin with grape seed extract, which is traditionally used in herbal medicine to help treat CVI. VeinEase uses 100% natural ingredients.
VeinEase provides antioxidants to help relieve symptoms related to non-complicated chronic venous insufficiency (CVI), such as sensation of swelling, heaviness and tingling of the legs.
AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal by product.
Take one capsule twice daily with/without food, or as directed by a qualified health care practitioner. Use for a minimum of one month to see beneficial effects.
Consult a health care practitioner prior to use if you are pregnant or breastfeeding, if you are taking any prescription medications, for use beyond three months or if symptoms persist or worsen.
- Chronic Venous Insufficiency (CVI)
- Varicose veins
The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.
Non-medicinal Ingredients: dicalcium phosphate and sodium stearyl fumarate. Capsule: hypromellose.
Flavonoids for CVI
The 10:1 mixture of diosmin and hesperidin has been found to be effective in all stages of CVI. The mixture improves venous tone in women at risk for varicose veins, and there is a correlation between varicose veins and CVI.
Reduced CVI Symptoms
Earlier signs and symptoms of CVI include edema in the leg and superficial skin changes. In one study, subjects with CVI were divided into two groups: those with and without venous reflux. The mixture of diosmin and hesperidin at a 10:1 ratio improved leg heaviness and edema (leg circumference) in both groups equally. Larger improvements were made in the non-reflux group for pain, cramps, and sensation of swelling. Venous reflux is associated with more severe CVI and occurs when blood flows back through the one-way valves down the leg, and it usually produces skin ulcers.
The clinically tested mixture of 10:1 diosmin and hesperidin helps speed leg ulcer healing. Some people experience complete healing along with standard ulcer care, which typically includes compression stockings, leg elevation and local wound care. One study found that the mixture improved time to complete healing (16 vs 21 weeks), but that it took about 8 weeks to show favour for the mixture vs. the control group. A meta-analysis found that within 6 months, those being treated with a diosmin and hesperidin mixture had a 32% improved chance of complete healing from skin ulcers, and that the healing process was shortened by 5 weeks. It also suggested that this treatment was most effective for ulcers with a size between 5-10 cm2 and that had been present for 6-12 months, and it has been suggested that standard ulcer care may be sufficient for small or new ulcers.
Quality of Life
More subjectively but equally as important for those suffering from CVI, treatment with the 10:1 mixture of diosmin and hesperidin and its results also improved the subjects’ quality of life scores.
Mechanisms of Action
Anti-inflammatory and venous tone: Studies have measured many physiological changes that occur with the treatment of diosmin and hesperidin. The generally accepted mechanisms of action include anti-inflammatory effects and improved venous tone.
Calcium regulation: One study found that the mixture increases calcium sensitivity of vascular smooth muscle, improving contractions and tension in the veins. Calcium is vital in regulating muscle contractions, and blood vessels are a type of muscle.
Antioxidant and adhesion molecules: Another study also found that the mixture inhibits free radical and prostaglandin synthesis, reduces microvascular leakage, and reduces leukocyte activity, trapping and migration.
Hypoxia and inflammation: Venous blood does still contain some oxygen, just enough to supply the cells of the veins to function since they require oxygen just as much as any other cell. In CVI, blood pooling results in reduced blood flow, which means that less oxygen is reaching the venous cells and the surrounding tissues such as skin and fat cells. This then results in a drop in energy (ATP) production by these cells, resulting in the vicious cycle of inflammation and further injury. The diosmin and hesperidin mixture improves microcirculation, oxygen partial pressure (PO2) in the blood and oxygen saturation, and decreases carbon dioxide partial pressure (PCO2). It also helped reduce the drop in ATP production by the venous cells, reducing the perpetuation of inflammation and damage.
Other benefits of diosmin: Diosmin is known to be a phlebotonic and has been shown to reduce lymphedema and limb volume and increases lymphatic drainage. Diosmin decreases red blood cell aggregation, which can help improve blood flow and capillary filtration in diabetes. It also reduced HbA1c (a blood glucose measure that is used to assess diabetic severity) and increased glutathione peroxidase (antioxidant) levels. This is excellent news for those struggling with the side effects of diabetes! Diosmin has also been shown to have chemopreventive and antiproliferative effects in animal and in vitro studies.
Grape Seed Extract for CVI
Grape seed extract is an antioxidant, protecting vessels from injury and from the furthering of CVI complications. It may also help maintain a healthy blood pressure and reduce edema. Since the presence of skin ulcers is directly proportional to venous pressure, improving venous blood pressure may help reduce skin ulcers.
One study administered 100 mg a of grape seed extract per day and found symptom improvements in 80% of subjects in as little as 10 days, including itching, heaviness, pain, and edema. Itching disappeared in 80% of patients. Pain disappeared in 53% of patients.
Safety and Toxicity
Animal studies showed no toxicity after 26 weeks of supplementation of a mixture of 90% diosmin and 10% hesperidin with doses of 35 times that recommended.
A mixture of diosmin and hesperidin taken by pregnant and nursing women for hemorrhoids did not affect fetus. However, consulting a health care professionnel in pregnancy and nursing is still recommended.
Diosmin may inhibit CYP 450 (phase I enzymes), so be careful in taking this product with drugs. No adverse events with blood thinning medications have occurred, but diosmin does have a slight blood thinning effect.