Magnesium + Taurine

AOR04324

Supports Cardiovascular Function

  • Helps maintain healthy blood pressure
  • Prevents over-excitability of the central nervous system
  • Magnesium Taurate provides a correct ratio of magnesium and taurine
Gluten Free
Non-GMO
Soy Free
Vegan

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Magnesium Taurine is an advanced formula for improving overall cardiovascular health.  Taurine and magnesium have both been shown to improve cardiac health, improve insulin sensitivity, and inhibit neuromuscular excitability. They both share similar actions including anti-arrhythmic, antihypertensive and cardio-protective effects. Both magnesium and taurine appear to balance calcium levels in the heart, thus influencing contractility and protecting the heart against potential difficulties caused by an overload of heart calcium levels.

The majority of symptomatic heart patients have relative deficiencies of taurine, therefore restoring the level of taurine would seem essential to any strategy designed to benefit those with heart problems. Magnesium and taurine deficiencies have also been observed in diabetics, trauma patients, individuals requiring long term intravenous feeding and individuals with liver or kidney failure.

Supplementing with magnesium and taurine provides great cardiovascular benefits to these individuals. This combination helps to prevent potentially debilitating deficiencies, stabilize cell membranes, and inhibit the over-excitability of the central nervous system.

NPN

80043532

Discussion

Magnesium + Taurine helps the body metabolize carbohydrates, proteins, and fats. It also helps maintain proper muscle function, in the development and maintenance of bones and teeth, in tissue formation, and to support cardiovascular function.

Guarantees

AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Adult Dosage

Take 5 capsules daily to support cardiovascular function. To help regulate muscle function, support tissue formation, and to support the metabolism of fat, carbohydrates and protein, take 1 capsule one to five times daily. Take with or without food, or as directed by a qualified health care practitioner.

Cautions

Consult a health care practitioner prior to use if you are pregnant or breastfeeding.

  • Pharmaceutical synthesis
Main Applications
  • Cardiovascular support
  •  Neurological disorders
Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Serving Size: 1 Capsule
Amount Per Serving
Taurine
300 mg
Magnesium (citrate)
65 mg

Non-medical Ingredients: sodium stearyl fumarate. Capsule: hypromellose.

Background

Background Information

Magnesium Taurate is a combination of the mineral magnesium and the amino acid taurine, and is designed to help ensure heart health.  Heart problems are rampant in North America and much of the world. Magnesium Taurate has the potential, backed up by extensive research, to help deal with heart problems and minimize the havoc they cause in people’s bodies and lives. Don’t let your heart go undernourished or unprotected. Let Magnesium Taurate help your heart regulate itself and bring you improved heart health.  By supplementing with this amino-acid / essential mineral combination, the body’s ability to avoid potentially debilitating deficiencies, stabilize cell membranes and inhibit the over-excitability of the central nervous system is synergistically enhanced.

Magnesium for the Heart

Magnesium (Mg) is another mineral that is in startling short supply in modern society.  Too little magnesium directly affects your heart health, causing your blood pressure to elevate and dramatically raising your chances of a heart attack and/or stroke. Magnesium helps the heart muscles work together and the nerves that initiate the heartbeat to maintain their regular function and rhythm, and it minimizes the negative effects of heart ailments. As an electrolyte, magnesium helps to keep nerves and muscles active, regulate water levels, and maintain acid-base balance.

Magnesium for DNA Repair

Magnesium also has an important role in protecting the genome. It helps to stabilize DNA, since its positive charge balances the negative charge on DNA. It is also required as a cofactor by many of the enzymes that are involved in DNA repair. Furthermore, magnesium has been suggested to help protect against oxidative stress, a main cause of genetic damage, and against systemic inflammation, both of which can lead of cancer.

Taurine

The most abundant free amino acid to be found in the blood of all mammals, taurine is also concentrated within the heart where it regulates the beating.  It is now known to stabilize membranes, lower blood pressure, and stabilize heart rate (antiarrhythmic). Repeatedly, taurine has been shown to minimize the damaging effects of congestive heart failure. Sound familiar?

A Conditionally Essential Amino Acid for the Heart

An increasing volume of research is showing taurine’s effects on the cardiovascular system – and some of the results are astounding. The importance of taurine has not always been a central point of interest for scientists, probably because it has always been considered a “non-essential” amino acid, meaning the body can synthesize it internally. However, more recent revelations about its importance have been so numerous that scientists have been moving to re-classify it as “conditionally essential”. The anti-arrhythmic, cardioprotective, antihypertensive, and inotropic properties of taurine are remarkably similar to magnesium. Taurine modulates cytosolic heart calcium content and binding, thus influencing the heart’s ability to contract.

Antitoxin and Antioxidant

Taurine’s benefits aren’t limited to the cardiovascular system either. Its ability to stabilize membranes is bolstered by its antioxidant and antitoxin effects as well, since it protects the cellular membranes from toxic compounds such as oxidants, bile acids, and xenobiotics. These same protective effects help defend the heart from free radical damage as well.

 

Research

Magnesium Taurine: A Cardiovascular Combo

Recent studies have revealed that magnesium and taurine share a number of interchangeable and potentiating roles in human physiology. Studies have demonstrated that magnesium plays an important role in the metabolic regulation of taurine levels. Concurrently, taurine can fulfill magnesium’s biochemical functions in both overt and subclinical magnesium-deficient states. The four central areas where taurine and magnesium share common biological ground are: the ability to elicit overall improvements in cardiology, the potentiating effect on insulin sensitivity, the inhibitory effects on neuromuscular excitability, and the dependency on vitamin B6.

Magnesium Taurine in Blood Pressure and Blood Clotting

Both magnesium and taurine appear to act as physiologic calcium antagonists and thus may protect the heart against potential difficulties caused by an overload of heart calcium levels. Taurine and magnesium also modulate constriction and relaxation of the arteries and protect against the stresses which induce an unhealthy blood pressure level by inhibiting the central action of angiotensin II, a common target of blood pressure drugs. Both taurine and magnesium may also share a number of antithrombotic effects.

Magnesium Taurine Enhance Insulin Sensitivity

Both taurine and magnesium enhance the actions of insulin without stimulating the release of insulin itself from the pancreas. They instead enhance insulin sensitivity via the stimulation of glycogenesis, glycolysis and oxygen utilization.

Magnesium Taurine for Nerve Function

Both magnesium and taurine are relatively stable compounds that are both found in the central nervous system and in the peripheral tissue surrounding it. Both possess anticonvulsive capabilities, and the mechanisms of action that they both share for this capability includes their mutual effectiveness against the effects of hypoxia.

Magnesium Taurine Depend on Vitamin B6

Taurine and magnesium each share a conspicuously dependent relationship with vitamin B6. Studies have repeatedly shown that seriously lowered vitamin B6 levels have a depletive effect on both magnesium and taurine pools. This mutual dependency on B6 is one of the indicators that scientists have used to examine the parallel relationship between taurine and magnesium.

Population Surveys on Magnesium Intake

A 1977-78 study by the US Department of Agriculture found that the only 25% of people surveyed had a magnesium intake that was at or greater than the recommended daily allowance (RDA), meaning that 75% of the population was deficient. This is especially disturbing since the RDA amounts are almost always set significantly lower than what scientific research suggests. The reasons for the deficiency are all too familiar: too much processed food, depleted soil minerals, and stress. Epidemiological studies (long term observational studies that review population statistics) have shown that regions of the world that have ‘hard’ drinking water (water which is high in minerals including magnesium) have lower mortality rates from heart attacks.

Magnesium & Normal Cell Processes

A study of 1139 patients with newly diagnosed abnormal cell growth in the lung and 1210 healthy controls had their intake of dietary magnesium and their DNA repair capacity (DRC) assessed. After adjusting for potential confounding factors, the study found an inverse association between magnesium intake and the risk of abnormal cell growth in the lung. This decreased risk ranged from 17 to 53%. DRC was also correlated with magnesium intake. Low dietary magnesium and suboptimal DRC were associated with a substantial increase in risk lung problems. Therefore, magnesium’s protective roles in maintaining the structure of the cell and genome may reduce the risk of certain forms of lung diseases.

Magnesium & Heart Disease

In 2006, stable coronary artery disease (CAD) patients received oral magnesium for 6 months. Left ventricular function (LVEF) and heart rate deflection both improved at rest and during exercise, and exercise tolerance (VO2max) improved.

Magnesium given by injection has also been shown to aid recovery from heart problems. Heart patients that could not receive thrombolytic therapy (clot-dissolving therapy) were given magnesium sulphate by IV for 48 hours after their heart attack, or placebo. A follow-up 4.8 years later showed that those who had received the magnesium had significantly lower mortality rates, better left ventricle function (LVEF) and a lower incidence of heart problems. This shows that magnesium can play an important role in preserving long-term heart health after certain types of cardiovascular events.

 

Market Trends

Standalone magnesium supplements are very popular, especially among consumers looking to maintain or improve their heart health. It is well-known that typical North American diets are deficient in magnesium, and it is probably the most common mineral supplement used. It is not well-known, however, that taurine complements magnesiums roles, providing similar benefits and even making up for a magnesium deficiency in some ways.

AOR Advantage

This combination is based on compiled research showing that magnesium and taurine share many similar physiological functions especially in various cardioprotective effects, and that taurine can help fulfill the role of magnesium during deficiencies. AOR’s Magnesium Taurate provides a balanced amount of magnesium and taurine.

References

Ceremuzy?ski L, Gebalska J, Wolk R, Makowska E. Hypomagnesemia in heart failure with ventricular arrhythmias. Beneficial effects of magnesium supplementation. J Intern Med. 2000 Jan;247(1):78-86.

Finckenbeg P, et al. Magnesium supplementation prevents angiotensin II-induced myocardial damage and CTGF overexpression. J Hypertens 2005 Feb;23(2):375-80.

Mahabir S, Wei Q, Barrera SL, Dong YQ, Etzel CJ, Spitz MR and Forman MR. Dietary magnesium and DNA repair capacity as risk factors for lung cancer. Carcinogenesis 2008;29(5):949-956.

Marks AR. Calcium and the heart: a question of life and death. J. Clin. Invest. 111:597-600 (2003).

McCarty MF. Complementary Vascular-Protective Actions of Magnesium and Taurine: A Rationale for Magnesium Taurate. Medical Hypotheses (1996) 46. 89-100.

McCarty MF. Magnesium taurate for the prevention and treatment of pre-eclampsia/eclampsia. Med Hypotheses. 1996 Oct;47(4):269-72.

Pokan R, Hofmann P, von Duvillard SP, Smekal G, Wonisch M, Lettner K, Schmid P, Shechter M, Silver B, Bachl N. Oral magnesium therapy, exercise heart rate, exercise tolerance, and myocardial function in coronary artery disease patients. Br J Sports Med. 2006 Sep;40(9):773-8.

Schaffer SW, Lombardini JB, Azuma J. Interaction between the actions of taurine and angiotensin II. Amino Acids. 2000;18(4):305-18.

Shechter M, Hod H, Rabinowitz B, Boyko V, Chouraqui P.Long-term outcome of intravenous magnesium therapy in thrombolysis-ineligible acute myocardial infarction patients. Cardiology. 2003;99(4):205-10.

 

Abstract

Oral magnesium therapy, exercise heart rate, exercise tolerance, and myocardial function in coronary artery disease patients.

Br J Sports Med. 2006 Sep;40(9):773-8.

Pokan R, Hofmann P, von Duvillard SP, Smekal G, Wonisch M, Lettner K, Schmid P, Shechter M, Silver B, Bachl N.

BACKGROUND: Previous studies have demonstrated that in patients with coronary artery disease (CAD) upward deflection of the heart rate (HR) performance curve can be observed and that this upward deflection and the degree of the deflection are correlated with a diminished stress dependent left ventricular function. Magnesium supplementation improves endothelial function, exercise tolerance, and exercise induced chest pain in patients with CAD.

PURPOSE: We studied the effects of oral magnesium therapy on exercise dependent HR as related to exercise tolerance and resting myocardial function in patients with CAD.

METHODS: In a double blind controlled trial, 53 male patients with stable CAD were randomised to either oral magnesium 15 mmol twice daily (n = 28, age 61 /-9 years, height 171 /-7 cm, body weight 79 /-10 kg, previous myocardial infarction, n = 7) or placebo (n = 25, age 58 /-10 years, height 172 /-6 cm, body weight 79 /-10 kg, previous myocardial infarction, n = 6) for 6 months. Maximal oxygen uptake (VO2max), the degree and direction of the deflection of the HR performance curve described as factor k

RESULTS: Magnesium therapy for 6 months significantly increased intracellular magnesium levels (32.7 /-2.5 v 35.6 /-2.1 mEq/l, p

CONCLUSION: The present study supports the intake of oral magnesium and its favourable effects on exercise tolerance and left ventricular function during rest and exercise in stable CAD patients.

 

Long-term outcome of intravenous magnesium therapy in thrombolysis-ineligible acute myocardial infarction patients.

Cardiology. 2003;99(4):205-10.

Shechter M, Hod H, Rabinowitz B, Boyko V, Chouraqui P.

The aim of our study was to analyze the long-term survival and cardiac function in 194 consecutive, thrombolysis-ineligible acute myocardial infarction (AMI) patients receiving 48-hour intravenous magnesium sulfate (22 g) – 96 patients, compared with placebo – 98 patients. After a mean 4.8-year follow-up, all-cause mortality and cardiac mortality were significantly lower in the magnesium compared to the placebo group [(18 vs. 33 patients, p < 0.01) and (12 vs. 30 patients, p < 0.001), respectively]. Rest radionuclide ventriculography tests for left-ventricular ejection fraction (LVEF) were assessed in surviving patients up to completion of follow-up. Magnesium-treated patients had a significantly higher LVEF (0.51 /- 0.10 vs. 0.44 /- 0.14, p < 0.05) and a lower incidence of heart failure compared to placebo-treated patients (12 vs. 3 patients, p = 0.02). Beneficial effects of intravenous magnesium therapy in thrombolysis-ineligible AMI patients appeared to last for at least 4.8 years, concomitant with preserved LVEF, suggesting a favorable role for acute magnesium treatment in these patients.

 

 

Complementary vascular-protective actions of magnesium and taurine: a rationale for magnesium taurate.

Med Hypotheses. 1996 Feb;46(2):89-100.

McCarty MF.

By a variety of mechanisms, magnesium functions both intracellularly and extracellularly to minimize the cytoplasmic free calcium level, [Ca2 ]i. This may be the chief reason why correction of magnesium deficiency, or induction of hypermagnesemia by parenteral infusion, exerts antihypertensive, anti-atherosclerotic, anti-arrhythmic and antithrombotic effects. Although the amino acid taurine can increase systolic calcium transients in cardiac cells (and thus has positive inotropic activity), it has other actions which tend to reduce [Ca2 ]i. Indeed, in animal or clinical studies, taurine lowers elevated blood pressure, retards cholesterol-induced atherogenesis, prevents arrhythmias and stabilizes platelets–effects parallel to those of magnesium. The complex magnesium taurate may thus have considerable potential as a vascular-protective nutritional supplement, and might also be administered parenterally, as an alternative to magnesium sulfate, in the treatment of acute myocardial infarction as well as of pre-eclampsia. The effects of magnesium taurate in diabetes deserve particular attention, since both magnesium and taurine may improve insulin sensitivity, and also may lessen risk for the micro- and macrovascular complications of diabetes.

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