From 2013 this preclinical review examined benefits and drawbacks of various proline analogues. L-Proline analogues have been proven to be valuable reagents for studying cellular metabolism and the regulation of macromolecule synthesis in both prokaryotic and eukaryotic cells. They are also promising candidates for tuning the biological, pharmaceutical, or physicochemical properties of naturally occurring or […]
A randomized, double-blind, placebo-controlled trial was designed to test the ability of Probiotic-3 to reduce symptoms associated with acute infectious diarrhea. The study focused on 304 children between three months and six years of age admitted to a primary care centre with viral or bacterial infections. Duration of diarrhea was 30% shorter in children receiving […]
The effect of Pyrroloquinoline quinone (PQQ) on cognition was tested in 41 healthy elderly subjects. Subjects were given 20 mg of PQQ or placebo for 12 weeks. In the group with the lowest initial score on visual-spatial cognitive function (via laptop tablet Touch M), scores were significantly increased after PQQ supplementation. Researchers also noted that […]
In this study of healthy women, participants were randomized to receive a placebo or MBP at 40 mg per day for six months. A significant increase in BMD and a decrease in bone metabolism and bone loss was observed in the MBP group, compared to the placebo group. The authors conclude that the increase in […]
This review from 2017 assessed the relationship between biotin supplementation and hair loss. With 18 studies reviewed the authors found that while biotin supplementation was effective, it was only shown to be helpful if an underlying biotin deficiency was established. References: Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for […]
This 2017 meta-analysis used randomized controlled trials to determine the efficacy and safety of PEA for treating chronic pain. Ten studies were identified for review, eight of these studies were randomized controlled trials with 743 patients receiving PEA and 460 patients receiving inactive controls. Analysis of the results of these trials found that PEA supplementation […]
In this 2021 comprehensive review, the pharmacological effects of diosmin in vitro and in vivo studies are reviewed. Evidence of anti-inflammatory, antioxidant, antidiabetic, antihyperlipidemic and antifibrotic effects in different disease models are presented. References: Gerges SH, Wahdan SA, Elsherbiny DA, El-Demerdash E. Pharmacology of Diosmin, a Citrus Flavone Glycoside: An Updated Review. Eur J Drug […]
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