Research Category: Preclinical

Effect of BCAA intake during endurance exercises on fatigue substances, muscle damage substances and energy metabolism substances 

To determine the effects of BCAA supplementation on fatigue, muscle damage and energy metabolism after endurance exercise, this randomized, double-blind, placebo-controlled clinical trial from 2013 was carried out. These results suggest that BCAA may reduce muscle damage associated with endurance exercise.  

Antioxidant capacity of different fractions of vegetables and correlation with the contents of ascorbic acid, phenolics and flavonoids 

This 2011 study examined the antioxidant capacity of fractions of vegetables and pointed to an interesting observation, namely, that in vegetables with a number of flavonoids, the ascorbic acid had over ten times the bioavailability of synthetic vitamin C. Careful analysis revealed that the tannins and flavonoids such as quercetin were also considerably enhanced by […]

Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: An updated review of their molecular mechanisms and experimental models 

A 2015 study investigated the anti-inflammatory and antioxidant effects of two flavonoids: hesperidin and hesperetin. Researchers found that both these flavonoids activated not one, but two distinct pathways/functions of reducing and preventing oxidative damage.  References: Parhiz H, Roohbakhsh A, Soltani F, Rezaee R, Iranshahi M. Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and […]

Forskolin stimulation of adenylate cyclase in human thyroid membranes 

From 1985 this preclinical study set the stage for much of our mechanistic understanding of Coleus. Authors identified forskolin, the main active compound, may mainly act on the catalytic component of adenylate cyclase. Suggesting that it stimulates adenylate cyclase in human thyroid membranes by a novel mechanism that differs from TSH- or Gpp(NH)p-stimulation, and that […]

Biotin is required for the zinc homeostasis in the skin 

This preclinical study published in 2019 presents insights into the importance of maintaining healthy biotin levels to prevent skin and hair changes often seen with zinc deficiency.  References: Ogawa Y, Kinoshita M, Sato T, Shimada S, Kawamura T. Biotin Is Required for the Zinc Homeostasis in the Skin. Nutrients. 2019 Apr 24;11(4):919. doi: 10.3390/nu11040919. PMID: […]

Effect of citric acid supplements to a maize-soya diet on the in vitro availability of minerals, trace elements and heavy metals 

This preclinical study from 1998 demonstrated the citric acid stabilizing and enhanced dialysability effect on other minerals calcium, magnesium, manganese and zinc.  References: Walter A, Rimbach G, Most E, Pallauf J. Effect of citric acid supplements to a maize-soya diet on the in vitro availability of minerals, trace elements, and heavy metals. Zentralbl Veterinarmed A. […]

The antimicrobial effects of deglycyrrhizinated licorice root extract on Streptococcus mutans UA159 in both planktonic and biofilm cultures 

In an in vitro study, DGL was effective at inhibiting a strain of Streptococcus mutans and preventing biofilm formation. Researchers suggest that the antimicrobial effects of DGL on S. mutans could lead to the development of DGL oral hygiene products.  References: Ahn S-J, Cho E-J, Kim H-J, et al. (2012). The antimicrobial effects of deglycyrrhizinated […]

Proline improves cardiac remodeling following myocardial infarction and attenuates cardiomyocyte apoptosis via redox regulation 

The authors investigated the therapeutic value of L-Proline (Pro), a nonessential amino acid against oxidative stress cardiovascular disease (CVD).  Findings suggested that Pro protects against MI injury at least partially via redox regulation, highlighting the potential of Pro as a novel therapy for ischemic HF caused by CHD.  References: Wang J, Xue Z, Lin J, […]

A medicinal extract of Scutellaria baicalensis and Acacia catechu act as a dual inhibitor of COX and 5-LOX to reduce inflammation 

Univestin™ has over 15 human clinical studies and in a randomized, double-blind, placebo-controlled trial, going head to head with common over the counter NSAIDS in relieving joint pain, stiffness and joint immobility in subjects with OA. On the basis of these positive observations, it was concluded that the mechanism of dual COX/LOX inhibition may confer […]

The effects of hyaluronic acid on articular chondrocytes 

This preclinical study from 2005 forms the theoretical basis for which future investigations of HA use in degenerative joint conditions was based. The authors were able to demonstrate the beneficial impact of hyaluronic acid in joint spaces. While studies previously suggested that HA only offered temporary relief as a viscosupplementation therapy (restoring the elasticity and […]

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