Research Category: Review

The role of menaquinones (vitamin K₂) in human health 

This comprehensive review from 2013 offers insights into the health benefits of menaquinones as compared to phylloquinone. Citing biochemical as well as intervention studies demonstrating beneficial effects on bone parameters and cardiovascular health (coronary calcifications). Particularly noting that studies with benefits required very high doses of MK-4 (generally 45 mg) which are above what can […]

Stress-Induced Sensitization: the Hypothalamic–Pituitary–Adrenal Axis and Beyond 

This review of preclinical evidence published in 2015 outlines the long term impacts on the hypothalamic- pituitary- adrenal axis in response to both acute and chronic stress. Highlighting the importance of stress management for long term health.  References: Belda, X., Fuentes, S., Daviu, N., Nadal, R., & Armario, A. (2015). Stress-induced sensitization: the hypothalamic-pituitary-adrenal axis […]

Back to the roots – An overview of the chemical composition and bioactivity of selected root-essential oils 

From 2021 this comprehensive review covers evidence for the composition, preclinical and clinical indications of a number of root botanicals. Including Coleus forskolii. Identifying over 40 recovered compounds, sesquiterpene hydrocarbons, sesquiterpene alcohols, monoterpenoids and diterpenoids.  References: Lunz K, Stappen I. Back to the Roots-An Overview of the Chemical Composition and Bioactivity of Selected Root-Essential Oils. […]

Is Branched-Chain Amino Acids Supplementation an Efficient Nutritional Strategy to Alleviate Skeletal Muscle Damage? A Systematic Review 

This systematic review and meta-analysis reviewed the available clinical evidence for the use of BCAA supplementation in alleviating skeletal muscle damage, within the context of exercise induced muscle damage or muscle injury. Changes in indirect markers of muscle damage were considered as primary outcome measures. Secondary outcome measures were the extent of change in indirect […]

Properties, metabolisms, and applications of (L)-proline analogues 

From 2013 this preclinical review examined benefits and drawbacks of various proline analogues. L-Proline analogues have been proven to be valuable reagents for studying cellular metabolism and the regulation of macromolecule synthesis in both prokaryotic and eukaryotic cells. They are also promising candidates for tuning the biological, pharmaceutical, or physicochemical properties of naturally occurring or […]

Pharmacology of diosmin, a citrus flavone glycoside: An updated review 

In this 2021 comprehensive review, the pharmacological effects of diosmin in vitro and in vivo studies are reviewed. Evidence of anti-inflammatory, antioxidant, antidiabetic, antihyperlipidemic and antifibrotic effects in different disease models are presented.   References: Gerges SH, Wahdan SA, Elsherbiny DA, El-Demerdash E. Pharmacology of Diosmin, a Citrus Flavone Glycoside: An Updated Review. Eur J Drug […]

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