This study from 2016 is a randomized double-blind placebo-controlled trial, testing the dose-dependent effects of W. somnifera in patients with knee joint pain and discomfort. At the end of 12 weeks the high dose (i.e., 250 mg BID) group showed improvements earlier at 4 weeks and had a more significant reduction in the VAS scores for pain, stiffness and disability.
References:
Ramakanth GS, Uday Kumar C, Kishan PV, Usharani P. A randomized, double blind placebo controlled study of efficacy and tolerability of Withaina somnifera extracts in knee joint pain. J Ayurveda Integr Med. 2016;7(3):151-157. doi:10.1016/j.jaim.2016.05.003 https://pubmed.ncbi.nlm.nih.gov/27647541/
