This review from 2018 examines the role of molybdenum in the body and covers key sources, historical context, and clinical and preclinical data. In humans, only 4 enzymes requiring molybdenum have been identified to date: sulfite oxidase, xanthine oxidase, aldehyde oxidase and mitochondrial amidoxime-reducing component (mARC). Sulfite oxidase, an enzyme found in mitochondria, catalyzes oxidation […]
This 2023 study looked at Morus alba’s traditional uses, chemical components and pharmacological effects. The fruits of Morus alba have traditionally been used as an analgesic, anthelmintic, antibacterial, anti-rheumatic, diuretic, hypotensive, hypoglycemia, purgative, restorative, sedative tonic and blood stimulant. Various plant parts were used as a cooling, sedating, diuretic, tonic and astringent agent to treat […]
This 2015 review gives practical insights into the etiology, differential diagnosis and treatment of hypokalemia, including treatment strategies for patients with known risk factors. Because small potassium deficits in serum represent large body losses, potassium repletion requires substantial and prolonged supplementation. For patients with known risk factors for hypokalemia (e.g. hypertension, heart failure or diabetes), […]
This 2020 systematic review was conducted to clarify the use and effects of nitrate as a dietary supplement in endurance athletes trained in cyclic sports (repetitive movement sports). Statistically significant ergogenic results were obtained in eight (29.63%) of the 27 studies investigated, with significant results obtained for cardiorespiratory parameters and performance measures. Improvement in exercise […]
Methylsulfonylmethane (MSM) has become a popular dietary supplement used for a variety of purposes, including its most common use as an anti-inflammatory agent. It has been well-investigated in animal models, as well as in human clinical trials and experiments. A variety of health-specific outcome measures are improved with MSM supplementation, including inflammation, joint/muscle pain, oxidative […]
This systematic review evaluates the existing evidence from randomized controlled trials of methylsulfonylmethane (MSM) in the treatment of osteoarthritis (OA) to determine its efficacy and safety profile. In two of the MSM trials, involving 168 patients with OA of the knee (N=52 on active treatment), significant improvement in pain outcomes in the treatment group compared […]
This narrative review from 2021 summarizes recent primary evidence that elucidates the role of vitamin A and its derivatives on innate immune regulators through mechanisms that promote skin immunity and sustain the skin microbiome. Deficiencies in vitamin A have been linked to an increased susceptibility to skin infection and inflammation. References: Roche FC, Harris-Tryon TA. […]
This review from 2000 covers important insights into the role of vitamin A in its multiple forms on physiology. Preformed vitamin A (all-trans-retinol and its esters) and provitamin A (beta-carotene) are essential dietary nutrients that provide a source of retinol. Both retinyl esters and beta-carotene are metabolized to retinol. The retinoid-binding proteins on binding retinol […]
Early use of adrenal extract was conducted in the 1930’s in clinical settings, whereby much of the regulatory framework which banned active hormone use was likely not in place. Since then there has not been as rigorous investigation as one would like with new preparations of both whole extract and cortex. However, in 1985 French […]
In this review published in Integrative Medicine: A Clinician’s Journal in 2017, forms of B12 supplements with potential to mitigate B12-related genetic polymorphisms were compared for their bioavailability and utilization. The study had three objectives: (1) To summarize and compare assimilation pathways for four B12 forms; (2) to determine whether supplementation with a particular B12 […]
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