In a study of healthy menopausal women, the effect of MBP on bone metabolism was evaluated. The results show a significant mean rate gain of lumbar BMD in the MBP group, compared to the placebo group. The authors conclude that MBP supplementation effectively prevented bone loss in menopausal women, inhibited bone resorption, while maintaining the […]
From 2021, this six-week randomized, double-blind, placebo-controlled, clinical trial included 48 young and middle-aged recreationally trained runners. Authors concluded that NMN increases the aerobic capacity of humans during exercise training, and the improvement is likely the result of enhanced O2 utilization of the skeletal muscle. References: Liao B, et al. Nicotinamide mononucleotide supplementation enhances aerobic […]
Published in 2023 this randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial assessed for safety and tolerability of NMN on metabolic parameters that relate to aging. The results confirmed that orally administered NMN is absorbed and quickly converted into NAD in human blood. NAD blood levels were increased in a dose dependent manner. References: Yi […]
This preclincal study published in 2021, assessed the pharmacokinetics of long term selenomethionine supplementation (200 mcg over 32 months). Results indicated that total selenium content was 80% higher with supplementation. As expected, the Se mass of most pools increased with SeMet supplementation, because SeMet is incorporated into proteins in place of methionine. References: Patterson, B. […]
This study from 2016 is a randomized double-blind placebo-controlled trial, testing the dose-dependent effects of W. somnifera in patients with knee joint pain and discomfort. At the end of 12 weeks the high dose (i.e., 250 mg BID) group showed improvements earlier at 4 weeks and had a more significant reduction in the VAS scores […]
In 2008 this double-blind placebo controlled trial had 21 healthy, adult volunteers over the course of 4 weeks. Half of the volunteers were given a placebo and half were given 3g of AHCC daily. The study found that individuals taking AHCC had 55% more dendritic cells after 4 weeks than at baseline, and that they […]
This randomized, double-blind, placebo-controlled clinical study investigated the effects of astaxanthin supplementation on lipid profiles and oxidative stress biomarkers in obese and overweight individuals. The results showed a significant decrease in LDL cholesterol and ApoB in the astaxanthin supplemented group, compared to the placebo group. References: Kim, J. H., Chang, M. J., Choi, H. D., […]
Clinical study in 2022, published in Alzheimer’s and Dementia. Oxaloacetic acid increased glucose uptake and glutathione levels in the brain having positive and possible neuroprotective effects for patients with Alzheimer’s disease. References; Vidoni ED, Choi IY, Lee P, Reed G, Zhang N, Pleen J, Mahnken JD, Clutton J, Becker A, Sherry E, Bothwell R, Anderson […]
This 2021 open label active-controlled clinical trial followed osteoarthritic patients for 6 weeks. The intervention group received low-dose curcumagalactomannosides (CGM) (400 mg once daily) in OA subjects. The treatment was compared with a standard combination of 500 mg glucosamine hydrochloride (GLN) and 415 mg chondroitin sulphate (CHN), supplied as a single oral dose twice a […]
In 2014 researchers conducted a clinical trial with 308 women with a history of recurrent UTIs. Intervention was prophylactic treatment with either 2 g D-mannose powder, or 50 mg of the antibiotic nitrofurantoin, or in the third group no prophylactic treatment at all. There was a significantly greater rate of recurrent UTI in the group […]
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