Research Category: Review
A study published in the American Journal of Sports Medicine in 2014 consisting of a systematic review of 13 randomized controlled trials evaluated the effectiveness of 12 different agents in preserving articular cartilage of the knee and delaying the progression of osteoarthritis. Treatment with chondroitin sulfate showed a significant reduction in cartilage loss in three […]
In this literature review from 2019, the authors summarized the most recent findings on the efficacy and safety of CS in OA. Based on the results of studies presenting a low risk of bias, the most recent meta-analysis shows that only the pharmaceutical-grade CS may be considered as an appropriate background treatment for the management […]
A meta-analysis of randomized controlled trials published in the Journal of Orthopaedics Surgery and Research in 2018 assessed the symptomatic effectiveness and safety of oral symptomatic slow-acting drugs (SYSADOAs) on the treatment of knee and/or hip osteoarthritis, such as chondroitin, glucosamine, and combination treatment with chondroitin plus glucosamine. Twenty-six articles describing 30 trials met the […]
This meta-analysis from 2011 assessed the effects of cinnamon extracts on blood glucose in patients with type 2 diabetes and/or prediabetes. Eight clinical studies designed as randomized, placebo-controlled trials were included. Authors concluded that results of the eight studies demonstrated statistically significant benefits for type 2 diabetics or prediabetics for lowering their blood glucose. References: […]
This comprehensive 2017 review assessed human clinical data that outlined the important relationship between flavonoids from citrus fruits and cardiovascular disease. Several high-profile studies were reviewed such as the prolific Nurses Healthy study, the large-scale Polish study, and a number of Japanese studies. All of which showed bioflavonoids have shown cardioprotective properties through correlations between […]
From 2017 this meta analysis included nine trials involving 428 subjects assessing the effects of CoQ10 on serum levels of inflammatory markers in people with metabolic diseases. Pooled data found CoQ10 supplementation significantly improved the serum level of CoQ10 and decreased inflammatory marker TNF-α. However, there was variability in the impact on CRP. References: Zhai […]
This systematic review published in 2021 assessed the health promoting effects of piperine found in black pepper (Piper nigrum). Piperine has also been documented for its hepatoprotective, anti-allergic, anti-inflammatory and neuroprotective properties. References: Haq, I. U., Imran, M., Nadeem, M., Tufail, T., Gondal, T. A., & Mubarak, M. S. (2021). Piperine: A review of its […]
Another recent review of the benefits of piperine was published in 2022. It includes a critical assessment of research outlining the extraction and isolation strategies, physicochemical properties and pharmacological activity. It also speaks to mechanisms of piperine biotransformation of co-administered drugs and how that can be used in industry for bioavailability enhancement of other compounds. […]
This review from 2019 examines both the in vitro and in vivo methods/models and clinical studies for the use of sulfurophane in health. References: Vanduchova A, Anzenbacher P, Anzenbacherova E. Isothiocyanate from Broccoli, Sulforaphane, and Its Properties. J Med Food. 2019 Feb;22(2):121-126. doi: 10.1089/jmf.2018.0024. Epub 2018 Oct 27. PMID: 30372361. https://pubmed.ncbi.nlm.nih.gov/30372361/
A double-blind, placebo-controlled study by Kapoor et al., in 2016 found 100 patients with coronary artery disease given 500 mg arjuna twice daily in addition to conventional therapy had significant decreases in hyperlipidemia and in multiple inflammatory cytokines including IL-6 and TNF-alpha. References; Amalraj A, Gopi S. (2016). Medicinal properties of Terminalia arjuna (Roxb.) Wight […]
