Due to human and animal research, a variety of nutritional and botanical substances (e.g., adaptogenic herbs, ascorbic acid, vitamin B1 and B6, coenzyme forms of vitamin B5 and B12, amino acid tyrosine and many more) appear to allow individuals to sustain adaptive responses that could minimize some systemic effects of stress. Systemic effects of stress […]
in 2011, this triple-blinded RCT examined the effects of pantethine 600 (for the first 8 weeks) and 900 (for the second 8 weeks) mg/day in 120 subjects over 16 weeks. Subjects all met criteria for low to moderate CVD risk and completed 4 weeks of the TLC diet at baseline and then initiated treatment with […]
This 2022 review provides an up-to-date evaluation of the current understanding of the cardioprotective mechanisms of vitamin B6. Marginal vitamin B6 deficiency appears to relate to an increased risk of inflammation-related diseases, such as cardiovascular diseases and cancers. Of all the cardiovascular diseases, heart failure is a complex clinical syndrome associated with a high mortality […]
Published in 2018, this human, clinical “investigator-blinded” trial examined 264 subjects who were suffering from high levels of stress and low serum magnesium levels but were otherwise healthy adults. The interventions were a magnesium–vitamin B6 (daily dose 300 mg and 30 mg respectively) or magnesium alone (daily dose 300 mg) for 8 weeks. Overall, both […]
This 2021 review summarizes vitamin B6’s role in biochemical pathways and considers whether its deficiency may be associated with various diseases such as diabetes, heart disease, cancer or the prognosis of COVID-19. It is active in the metabolism of carbohydrates, lipids, amino acids and nucleic acids, and participates in cellular signaling. It is an antioxidant […]
In this comparison study, the bioavailability of MK-4 and MK-7 and subsequent changes in serum levels in healthy volunteers was examined in two separate experiments. MK-7 as low as 60 mcg resulted in measurable levels. Given that MK-4 still has a unique, rapid acting effect in up regulating osteocalcin and matrix GLA in addition to […]
This comprehensive review from 2013 offers insights into the health benefits of menaquinones as compared to phylloquinone. Citing biochemical as well as intervention studies demonstrating beneficial effects on bone parameters and cardiovascular health (coronary calcifications). Particularly noting that studies with benefits required very high doses of MK-4 (generally 45 mg) which are above what can […]
This review of preclinical evidence published in 2015 outlines the long term impacts on the hypothalamic- pituitary- adrenal axis in response to both acute and chronic stress. Highlighting the importance of stress management for long term health. References: Belda, X., Fuentes, S., Daviu, N., Nadal, R., & Armario, A. (2015). Stress-induced sensitization: the hypothalamic-pituitary-adrenal axis […]
From 2021 this comprehensive review covers evidence for the composition, preclinical and clinical indications of a number of root botanicals. Including Coleus forskolii. Identifying over 40 recovered compounds, sesquiterpene hydrocarbons, sesquiterpene alcohols, monoterpenoids and diterpenoids. References: Lunz K, Stappen I. Back to the Roots-An Overview of the Chemical Composition and Bioactivity of Selected Root-Essential Oils. […]
This systematic review and meta-analysis reviewed the available clinical evidence for the use of BCAA supplementation in alleviating skeletal muscle damage, within the context of exercise induced muscle damage or muscle injury. Changes in indirect markers of muscle damage were considered as primary outcome measures. Secondary outcome measures were the extent of change in indirect […]
Your cart is empty
Add something you love and it will show up here.
