In a double-blind, placebo-controlled study from 2014, 114 women aged 45-65 years were randomized to receive 2.5 g of a collagen peptide supplementation or placebo daily for eight weeks. Eye wrinkles were visibly and significantly reduced in the group given collagen (p<0.05) at 4 weeks and 8 weeks. Researchers also detected a significantly higher content […]
Following 12 weeks of supplementation, this randomized double blind placebo controlled trial had 98 subjects with high cholesterol. There was a significant decrease in total cholesterol, triglycerides, LDL-cholesterol and VLDL cholesterol levels in the amla supplementation group, compared to the placebo group. References: Upadya, H., Prabhu, S., Prasad, A., Subramanian, D., Gupta, S., & Goel, […]
This systematic review of clinical trials evaluating the effect of Amla on cardiovascular pharmacology was published in 2018. It included 19 cell culture, animal and human clinical studies with the terms “antioxidant, arrhythmia, cardioprotective, cardiotoxicity, heart disease, heart failure, hyperlipidemia, hypertension, myocardial dysfunction and oxidative stress”. References: Hashem-Dabaghian, F., Ziaee, M., Ghaffari, S., Nabati, F., […]
In this randomized, placebo-controlled clinical study, the effect of milk basic protein on bone mineral density (BMD) and bone density was evaluated in young women. The results showed an increase in BMD in all groups, compared to the baseline, with both milk and MBP groups showing a larger increase in BMD. Bone metabolism was also […]
In a study of healthy menopausal women, the effect of MBP on bone metabolism was evaluated. The results show a significant mean rate gain of lumbar BMD in the MBP group, compared to the placebo group. The authors conclude that MBP supplementation effectively prevented bone loss in menopausal women, inhibited bone resorption, while maintaining the […]
In the adult male study, healthy participants were given 300 mg MBP per day for 16 days and assessed for markers of bone loss. The results show a significant decrease in bone metabolism and bone loss. A decrease in urinary cross-linked N-teleopeptides of type-I collagen (NTx) excretion was also observed, suggesting that MBP promoted bone […]
From 2021, this six-week randomized, double-blind, placebo-controlled, clinical trial included 48 young and middle-aged recreationally trained runners. Authors concluded that NMN increases the aerobic capacity of humans during exercise training, and the improvement is likely the result of enhanced O2 utilization of the skeletal muscle. References: Liao B, et al. Nicotinamide mononucleotide supplementation enhances aerobic […]
Published in 2023 this randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial assessed for safety and tolerability of NMN on metabolic parameters that relate to aging. The results confirmed that orally administered NMN is absorbed and quickly converted into NAD in human blood. NAD blood levels were increased in a dose dependent manner. References: Yi […]
This systematic review published in 2021 assessed the health promoting effects of piperine found in black pepper (Piper nigrum). Piperine has also been documented for its hepatoprotective, anti-allergic, anti-inflammatory and neuroprotective properties. References: Haq, I. U., Imran, M., Nadeem, M., Tufail, T., Gondal, T. A., & Mubarak, M. S. (2021). Piperine: A review of its […]
Another recent review of the benefits of piperine was published in 2022. It includes a critical assessment of research outlining the extraction and isolation strategies, physicochemical properties and pharmacological activity. It also speaks to mechanisms of piperine biotransformation of co-administered drugs and how that can be used in industry for bioavailability enhancement of other compounds. […]
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