Research Category: Health Conditions
In this comprehensive review from 2020, authors examined evidence supporting the use of bergamot polyphenolic fractions in prevention of metabolic syndrome. Including research on the lipid lowering and anti-diabetic effects of the polyphenols in bergamot. References: Carresi, C., Gliozzi, M., Musolino, V., Scicchitano, M., Scarano, F., Bosco, F., Nucera, S., Maiuolo, J., Macrì, R., Ruga, […]
This systematic review published in 2020 reviewed 12 articles related to the lipid modifying properties of bergamot extracts. Authors reported most studies demonstrated a significant decrease in total cholesterol (12.3% to 31.3%,), triglycerides (11.5% to 39.5%) and LDLc (7.6% to 40.8%). Eight trials reported HDLc increase after intervention with bergamot. References: Lamiquiz-Moneo, I., Giné-González, […]
This 2011 study examined the antioxidant capacity of fractions of vegetables and pointed to an interesting observation, namely, that in vegetables with a number of flavonoids, the ascorbic acid had over ten times the bioavailability of synthetic vitamin C. Careful analysis revealed that the tannins and flavonoids such as quercetin were also considerably enhanced by […]
This comprehensive 2017 review assessed human clinical data that outlined the important relationship between flavonoids from citrus fruits and cardiovascular disease. Several high-profile studies were reviewed such as the prolific Nurses Healthy study, the large-scale Polish study, and a number of Japanese studies. All of which showed bioflavonoids have shown cardioprotective properties through correlations between […]
A 2015 study investigated the anti-inflammatory and antioxidant effects of two flavonoids: hesperidin and hesperetin. Researchers found that both these flavonoids activated not one, but two distinct pathways/functions of reducing and preventing oxidative damage. References: Parhiz H, Roohbakhsh A, Soltani F, Rezaee R, Iranshahi M. Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and […]
This randomized, double-blind, placebo-controlled clinical study from 2015 showed that MS patients receiving 500 mg/day of CoQ10 for 12 weeks presented with a significant decrease of inflammatory cytokine. CoQ10 also alleviates markers of CNS inflammation. References: Sanoobar M, Eghtesadi S, Azimi A, Khalili M, Khodadadi B, Jazayeri S, Gohari MR, Aryaeian N. Coenzyme Q10 supplementation […]
From 2017 this meta analysis included nine trials involving 428 subjects assessing the effects of CoQ10 on serum levels of inflammatory markers in people with metabolic diseases. Pooled data found CoQ10 supplementation significantly improved the serum level of CoQ10 and decreased inflammatory marker TNF-α. However, there was variability in the impact on CRP. References: Zhai […]
In a randomized, double-blind controlled trial from 2015, 30 overweight or obese participants were given either 250 mg C. forskohlii extract or placebo twice daily for 12 weeks. Participants in both groups were to follow a hypocaloric diet throughout the study. At the end of the study both groups had significant reductions in hip and […]
From 1985 this preclinical study set the stage for much of our mechanistic understanding of Coleus. Authors identified forskolin, the main active compound, may mainly act on the catalytic component of adenylate cyclase. Suggesting that it stimulates adenylate cyclase in human thyroid membranes by a novel mechanism that differs from TSH- or Gpp(NH)p-stimulation, and that […]
In a double-blind, placebo-controlled trial from 2018, 53 women aged 40-60 years were randomized to receive 1000 mg of low-molecular weight collagen peptide supplement (a fish-derived collagen hydrolysate) or placebo, daily for 12 weeks. The group given collagen had significantly higher values of skin-hydration after 6 weeks and 12 weeks. Several parameters of skin elasticity […]
